干旱区生态环境知识资源中心(Arid): The MEDEA childhood asthma study design for mitigation of desert dust health effects: implementation of novel methods for assessment of air pollution exposure and lessons learned

Arid

DOI	10.1186/s12887-020-02472-4
	The MEDEA childhood asthma study design for mitigation of desert dust health effects: implementation of novel methods for assessment of air pollution exposure and lessons learned
	Kouis, Panayiotis; Papatheodorou, Stefania I.; Kakkoura, Maria G.; Middleton, Nicos; Galanakis, Emmanuel; Michaelidi, Eleni; Achilleos, Souzana; Mihalopoulos, Nikolaos; Neophytou, Marina; Stamatelatos, Gerasimos; Kaniklides, Christos; Revvas, Efstathios; Tymvios, Filippos; Savvides, Chrysanthos; Koutrakis, Petros; Yiallouros, Panayiotis K.
通讯作者	Kouis, P (corresponding author), Univ Cyprus, Med Sch, Resp Physiol Lab, Nicosia, Cyprus. ; Kouis, P (corresponding author), Shiakolas Educ Ctr Clin Med, Palaios Dromos Lefkosias Lemesou 215-6, CY-2029 Nicosia, Cyprus.
来源期刊	BMC PEDIATRICS
EISSN	1471-2431
出版年	2021
卷号	21 期号:1
英文摘要	BackgroundDesert dust events in Mediterranean countries, originating mostly from the Sahara and Arabian deserts, have been linked to climate change and are associated with significant increase in mortality and hospital admissions from respiratory causes. The MEDEA clinical intervention study in children with asthma is funded by EU LIFE+ program to evaluate the efficacy of recommendations aiming to reduce exposure to desert dust and related health effects.MethodsThis paper describes the design, methods, and challenges of the MEDEA childhood asthma study, which is performed in two highly exposed regions of the Eastern Mediterranean: Cyprus and Greece-Crete. Eligible children are recruited using screening surveys performed at primary schools and are randomized to three parallel intervention groups: a) no intervention for desert dust events, b) interventions for outdoor exposure reduction, and c) interventions for both outdoor and indoor exposure reduction. At baseline visits, participants are enrolled on MEDena (R) Health-Hub, which communicates, alerts and provides exposure reduction recommendations in anticipation of desert dust events. MEDEA employs novel environmental epidemiology and telemedicine methods including wearable GPS, actigraphy, health parameters sensors as well as indoor and outdoor air pollution samplers to assess study participants' compliance to recommendations, air pollutant exposures in homes and schools, and disease related clinical outcomes.DiscussionThe MEDEA study evaluates, for the first time, interventions aiming to reduce desert dust exposure and implement novel telemedicine methods in assessing clinical outcomes and personal compliance to recommendations. In Cyprus and Crete, during the first study period (February-May 2019), a total of 91 children participated in the trial while for the second study period (February-May 2020), another 120 children completed data collection. Recruitment for the third study period (February-May 2021) is underway. In this paper, we also present the unique challenges faced during the implementation of novel methodologies to reduce air pollution exposure in children. Engagement of families of asthmatic children, schools and local communities, is critical. Successful study completion will provide the knowledge for informed decision-making both at national and international level for mitigating the health effects of desert dust events in South-Eastern Europe.Trial registrationClinicalTrials.gov: NCT03503812, April 20, 2018.
英文关键词	Desert dust Asian dust Asthma Children Public health intervention
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000608271200002
WOS类目	Pediatrics
WOS研究方向	Pediatrics
来源机构	University of Oxford
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/347762
作者单位	[Kouis, Panayiotis; Kakkoura, Maria G.; Yiallouros, Panayiotis K.] Univ Cyprus, Med Sch, Resp Physiol Lab, Nicosia, Cyprus; [Kouis, Panayiotis] Shiakolas Educ Ctr Clin Med, Palaios Dromos Lefkosias Lemesou 215-6, CY-2029 Nicosia, Cyprus; [Papatheodorou, Stefania I.; Achilleos, Souzana] Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus; [Papatheodorou, Stefania I.] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; [Kakkoura, Maria G.] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England; [Kakkoura, Maria G.] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England; [Middleton, Nicos] Cyprus Univ Technol, Dept Nursing, Limassol, Cyprus; [Galanakis, Emmanuel; Michaelidi, Eleni] Univ Crete, Sch Med, Iraklion, Crete, Greece; [Mihalopoulos, Nikolaos] Univ Crete, Dept Chem, Iraklion, Greece; [Neophytou, Marina] Univ Cyprus, Dept Civil & Environm Engn, Nicosia, Cyprus; [Stamatelatos, Gerasimos] EnA Co...
推荐引用方式 GB/T 7714	Kouis, Panayiotis,Papatheodorou, Stefania I.,Kakkoura, Maria G.,et al. The MEDEA childhood asthma study design for mitigation of desert dust health effects: implementation of novel methods for assessment of air pollution exposure and lessons learned[J]. University of Oxford,2021,21(1).
APA	Kouis, Panayiotis.,Papatheodorou, Stefania I..,Kakkoura, Maria G..,Middleton, Nicos.,Galanakis, Emmanuel.,...&Yiallouros, Panayiotis K..(2021).The MEDEA childhood asthma study design for mitigation of desert dust health effects: implementation of novel methods for assessment of air pollution exposure and lessons learned.BMC PEDIATRICS,21(1).
MLA	Kouis, Panayiotis,et al."The MEDEA childhood asthma study design for mitigation of desert dust health effects: implementation of novel methods for assessment of air pollution exposure and lessons learned".BMC PEDIATRICS 21.1(2021).