Knowledge Resource Center for Ecological Environment in Arid Area
| 项目编号 | 31500002 |
| 基于单核苷酸多态性位点的军团菌系统分类和嗜肺军团菌分型研究 | |
| 詹晓勇 | |
| 主持机构 | 广州医科大学 |
| 开始日期 | 2016 |
| 结束日期 | 2018 |
| 资助经费 | 200000(CNY) |
| 项目类别 | 青年科学基金项目 |
| 资助机构 | CN-NSFC（国家自然科学基金） |
| 语种 | 中文 |
| 国家 | 中国 |
| 英文简介 | Legionella spp. are ubiquitous bacteria present in enviromental water systems. Inhalation of Legionella spp. in aerosolized water droplets from contaminated water sources is known to cause a type of pneumonia called Legionnaires’ disease (LD). To date, 58 Legionella species have been characterized, and 25 species are known to cause human disease. Legionella pneumophila is responsible for most of human infections and serogroup 1 alone accounts for almost 85% of cases. Several subtyping techniques including Pulsed-field gel electrophoresis (PFGE), Amplified fragment length polymorphism (AFLP) and Sequence-based typing (SBT) have been used to identify and characterize L. pneumophila strains. While, there have been some defections in these subtyping techniques (eg. Cannot distinguish clinical strains and envirronmental strarins). Therefore, further research on Legionella molecular genetics and developping more advanced stematics methods is needed..Single nucleotide polymorphism (SNP) refers to a single nucleotide mutation and polymorphism in the genome. SNPs are widely distributed in many species including bacteria, and are associated with bacteria virulence and antimicrobial resistance. The vast quantity, widely distribution of SNPs in the gnome of bacteria make it suitable for bacteria subtyping, especially those bacteria with complex trait and virulence factors. In the present study, we will research on more advanced systematics taxonomy methods of Legionella and molecular subtyping method for Legionella pneumophila based on the single nucleotide polymorphism of Legionella core gnome genes and virulence genes and compare it with SBT and muti-locus sequence typing. Our project is of great importance to bacterial evolution, pathogenic, pathogenic mechanism and outbreak control. |
| 中文关键词 | 军团菌 ; 嗜肺军团菌 ; 单核苷酸多态性 ; 系统发育 ; 分型 |
| 来源机构 | 广州医科大学 |
| 资源类型 | 项目 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/346913 |
| 推荐引用方式 GB/T 7714 | 詹晓勇.基于单核苷酸多态性位点的军团菌系统分类和嗜肺军团菌分型研究.2016. |
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