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Arid
项目编号360G-Wellcome-206742_Z_17_Z
Landscape changes, genetic structure of malaria vectors and their parasites in Senegal: impact on malaria epidemiology and control.
Dr El Hadji Amadou Niang
主持机构Universite Cheikh Anta Diop de Dakar
开始日期2019
结束日期2022
资助经费212999(GBP)
项目类别International Interview Committee
资助机构UK-WellcomeTrust（英国惠康基金）
语种英语
国家英国
英文简介Declining malaria incidence offers the opportunity to accelerate toward its elimination, which requires accurate information to target control where it is most needed and will deliver the greatest impact. The impact of environmental adaptation on vector populations, their vectorial capacity and susceptibility to control remain poorly understood. Anopheles arabiensisis common in arid areas, increasing in relative prevalence throughout sub-Saharan Africa, and is the dominant malaria-vector in Senegal. We aim to investigate how natural and anthropogenically-influenced landscape variation influences its genetic diversity, population structure and gene-flow, and how this may impact disease incidence, and aid targeting of vector control. We aim to test the hypothesis that its population structure in Senegal is impacted by both its prevailing environment and recent range expansions toward the more humid parts of the country. Furthermore, local adaptation, especially during this expansion, may have reduced genetic population sizes and genetic diversity, and gene flow between locally-adapted populations. Expected outcomes are:
  • Characterisation of An. arabiensis population structure and connectivity to provide predictions for targeted control
  • Understanding how genetic diversity, and potential adaptability/vulnerability of its populations depends on environment and range expansion
  • Investigation of how the above impact parasite diversity and vector blood feeding, and vectorial capacity.
    • 资源类型项目
    条目标识符http://119.78.100.177/qdio/handle/2XILL650/343816
    推荐引用方式
    GB/T 7714    		 Dr El Hadji Amadou Niang.Landscape changes, genetic structure of malaria vectors and their parasites in Senegal: impact on malaria epidemiology and control..2019.
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