Knowledge Resource Center for Ecological Environment in Arid Area
| 项目编号 | 1749419 |
| RAPID: Physiological and molecular mechanisms that explain reproductive-female-specific skeletal growth in a highly cooperative mammal, the Damaraland mole rat | |
| Jenny Tung | |
| 主持机构 | Duke University |
| 开始日期 | 2017-09-01 |
| 结束日期 | 2018-08-31 |
| 资助经费 | 108853(USD) |
| 项目类别 | Standard Grant |
| 资助机构 | US-NSF（美国国家科学基金会） |
| 项目所属计划 | Physiolgcl Mechnsms&Biomechnsm |
| 语种 | 英语 |
| 国家 | 美国 |
| 英文简介 | This RAPID award takes advantage of an ongoing experiment in the Kalahari Desert of South Africa on the Damaraland mole rat, a highly social mammal that cooperatively raises its young. The goal is to test hypotheses about how breeding drives bone growth and remodeling in females. Two bones that do and do not elongate in reproductive female mole rats (lumbar vertebrae and femur, respectively), and the same bones in nonreproductive females, will be compared for bone growth and bone-derived stem cell activity, mineralization potential, gene expression, and responsiveness to hormonal signals. The project will provide new information about how hormonal signals and hormonally-mediated gene expression changes result in bone growth that is related to fitness in this unusually cooperative mammal. Results will be broadly applicable to understanding the control of skeletal remodeling and growth in mammals. The project involves training of a postdoctoral fellow and volunteers at the Kalahari Research Centre in South Africa, and public education at the North Carolina Museum of Natural Sciences. This project will provide novel insight into the physiological and genomic targets of social evolution in the Damaraland mole rat. In females of this eusocial species, secondary skeletal growth (lumbar vertebrae elongation and widening of the pelvic girdle) is a function of reproductive activity and results in increased litter sizes. The project will investigate gene regulatory differences in bone-forming mesenchymal stem cells that explain this breeding female-specific growth phenotype. It will test the hypothesis that estrogen and insulin-like growth factor signaling differentiate reproductive females and non-breeders, and bones that experience secondary growth from those that do not. Differences in stem cell gene expression and chromatin accessibility at estrogen-receptor transcription-factor binding sites will be quantified. By elucidating the physiological mechanisms underlying permanent, secondary skeletal growth in mole rat females, the results will lead to a better understanding of how skeletal growth in adult mammals, including humans, is controlled. |
| 来源学科分类 | Biological Sciences |
| URL | https://www.nsf.gov/awardsearch/showAward?AWD_ID=1749419 |
| 资源类型 | 项目 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/341643 |
| 推荐引用方式 GB/T 7714 | Jenny Tung.RAPID: Physiological and molecular mechanisms that explain reproductive-female-specific skeletal growth in a highly cooperative mammal, the Damaraland mole rat.2017. |
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