Arid
项目编号9317885
Collaborative Research: Ecological and Evolutionary Genetics of P450 Genes in Desert Drosphila
James Fogleman
主持机构University of Denver
开始日期1994-02-01
结束日期1998-07-31
资助经费170584(USD)
项目类别Standard Grant
资助机构US-NSF(美国国家科学基金会)
项目所属计划POPULATION DYNAMICS
语种英语
国家美国
英文简介9317885 Fogleman/Mcintyre Cytochrome P450 genes produce enzymes that allow insects to tolerate poisonous chemicals such as insecticides and certain plant compounds. Some plants protect themselves from insects (and other herbivores) by making chemical compounds that are toxic in the animals which try to feed on them. Cytochrome P450 enzymes detoxify chemical compounds, usually by changing their chemical structure. The study of P450 genes, therefore, will provide information as to how insects become resistant to insecticides and/or plant defensive chemicals. %%% This proposal involves the use of an insect plant model system. The insects are fruit flies of the genus Drosophila, and the plants are columnar cacti which grow in the Sonoran Desert of Southwestern United States and Mexico. A wealth of background information on this model system has already been obtained including data on the ecology and genetics of the fruit flies and identification and characterization of the toxic chemicals that the cacti produce. Employing modern techniques of molecular genetics, the experiments included in this proposal will investigate how P450 genes evolve and how they are regulated. A better understanding of the mechanisms by which insects evolve P450 mediated resistance and by which P450 resistance genes are genetically regulated would represent a major advancement in the areas of insect ecological genetics and evolution.
来源学科分类Biological Sciences
URLhttps://www.nsf.gov/awardsearch/showAward?AWD_ID=9317885
资源类型项目
条目标识符http://119.78.100.177/qdio/handle/2XILL650/341054
推荐引用方式
GB/T 7714
James Fogleman.Collaborative Research: Ecological and Evolutionary Genetics of P450 Genes in Desert Drosphila.1994.
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