干旱区生态环境知识资源中心(Arid): Phytochemical characterization of polyphenolic compounds with HPLC-DAD-ESI-MS and evaluation of lipid-lowering capacity of aqueous extracts from Saharan plant Anabasis aretioides (Coss & Moq.) in normal and streptozotocin-induced diabetic rats

Arid

	Phytochemical characterization of polyphenolic compounds with HPLC-DAD-ESI-MS and evaluation of lipid-lowering capacity of aqueous extracts from Saharan plant Anabasis aretioides (Coss & Moq.) in normal and streptozotocin-induced diabetic rats
	Farid Omar; Khallouki Farid; Akdad Morad; Breuer Andrea; Owen Robert Wyn; Eddouks Mohamed
来源期刊	Journal of Integrative Medicine
ISSN	2095-4964
出版年	2018
卷号	16 期号:3 页码:185-191
英文摘要	Objective: Anabasis aretioides (Coss & Moq.), a Saharan plant belonging to Chenopodiaceae family, is widely distributed in semi-desert areas from the Tafilalet region of Morocco. This plant is extensively used by local population against diabetes and cardiovascular disorders. The purpose of the study was to investigate the effect of the aqueous A. aretioides extract on lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats and to identify the polyphenolic compounds present. In addition, the in vitro antioxidant activity of the aqueous A. aretioides extract was also evaluated. Methods: The effect of an aerial part aqueous extract (APAE) of A. aretioides (5 mg/kg of lyophilized A. aretioides APAE) on plasma lipid profile was investigated in normal and STZ-induced diabetic rats (n = 6) after once daily oral administration for 15 days. The aqueous extract was tested for its 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical-scavenging activity. Polyphenolic compounds in the extracts were definitively characterized by high-performance liquid chromatography-diode array detection-electrospray ionization-mass spectrometry. Results: In diabetic rats, oral administration of A. aretioides APAE provoked a significant decrease in both plasma cholesterol and triglyceride levels from the first to the second week (P<0.01). A significant decrease on plasma triglyceride levels was also observed in normal rats (P<0.01), where the reduction was 53%. In addition, the phytochemical analysis revealed the presence of 12 polyphenolic compounds. Moreover, according to the DPPH radical-scavenging activity, the aqueous extract showed an in vitro antioxidant activity. Conclusion: Aqueous A. aretioides APAE exhibits lipid-lowering and in vitro antioxidant activities. Many polyphenols were present in this extract and these phytoconstituents may be involved in the pharmacological activity of this plant.
英文关键词	Anabasis aretioides 1,1-Diphenyl-2-picrylhydrazyl Antioxidant activity Phytochemical analysis Lipid metabolism Polyphenolic compounds
类型	Article
语种	英语
收录类别	CSCD
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:6242415
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/335957
作者单位	Farid Omar, Team of Physiology & Endocrine Pharmacology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.; Akdad Morad, Team of Physiology & Endocrine Pharmacology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.; Eddouks Mohamed, Team of Physiology & Endocrine Pharmacology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.; Khallouki Farid, Team of Physiology & Endocrine Pharmacology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine;;Division of Preventive Oncology, National Center for Tumor Diseases, Im Neuenheimer Feld 460, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, ;;, Errachidia;;Heidelberg, Morocco;;Germany 52000;;.; Breuer Andrea, Division of Preventive Oncology, National Center for Tumor Diseases, Im Neuenheimer Feld 46...
推荐引用方式 GB/T 7714	Farid Omar,Khallouki Farid,Akdad Morad,et al. Phytochemical characterization of polyphenolic compounds with HPLC-DAD-ESI-MS and evaluation of lipid-lowering capacity of aqueous extracts from Saharan plant Anabasis aretioides (Coss & Moq.) in normal and streptozotocin-induced diabetic rats[J],2018,16(3):185-191.
APA	Farid Omar,Khallouki Farid,Akdad Morad,Breuer Andrea,Owen Robert Wyn,&Eddouks Mohamed.(2018).Phytochemical characterization of polyphenolic compounds with HPLC-DAD-ESI-MS and evaluation of lipid-lowering capacity of aqueous extracts from Saharan plant Anabasis aretioides (Coss & Moq.) in normal and streptozotocin-induced diabetic rats.Journal of Integrative Medicine,16(3),185-191.
MLA	Farid Omar,et al."Phytochemical characterization of polyphenolic compounds with HPLC-DAD-ESI-MS and evaluation of lipid-lowering capacity of aqueous extracts from Saharan plant Anabasis aretioides (Coss & Moq.) in normal and streptozotocin-induced diabetic rats".Journal of Integrative Medicine 16.3(2018):185-191.