干旱区生态环境知识资源中心(Arid): Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents

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	Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents
	Wang Bin; Li Ning; Deng Furong; Buglak Nicholas; Park George; Su Shu; Ren Aiguo; Shen Guofeng; Tao Shu; Guo Xinbiao
来源期刊	Journal of Environmental Sciences
ISSN	1001-0742
出版年	2016
卷号	47 页码:201-210
英文摘要	Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter (PM) exposure. The presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM < 2.5 mum (PM_(2.5) ) pollution in China have led to serious concerns regarding the health effects of PM_(2.5) during Asian sandstorms. We investigated how changes in PM_(2.5) composition, as the weather transitioned towards a sandstorm, affected human airway epithelial cells. Six PM_(2.5) samples covering two sandstorm events and their respective background and transition periods were collected in Baotou, an industrial city near the Gobi Desert in China. PM samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B, which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several metals. All PM samples potently increased the release of interleukin-6 (IL-6) and interleukin-8 (IL-8). Endotoxin in all samples contributed significantly to the IL-6 response, with only a minor effect on IL-8. Cr was positively correlated with both IL-6 and IL-8 release, while Si was only associated with the increase of IL-6. Our study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM.
英文关键词	Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings
类型	Article
语种	英语
收录类别	CSCD
WOS研究方向	Environmental Sciences & Ecology
CSCD记录号	CSCD:5793124
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/335702
作者单位	Wang Bin, Institute of Reproductive & Child Health,School of Public Health,Peking University, Ministry of Health Key Laboratory of Reproductive Health, Beijing 100191, China.; Ren Aiguo, Institute of Reproductive & Child Health,School of Public Health,Peking University, Ministry of Health Key Laboratory of Reproductive Health, Beijing 100191, China.; Li Ning, Department of Pathobiology & Diagnostic Investigation,College of Veterinary Medicine,Michigan State University, East Lansing, 48824, USA.; Buglak Nicholas, Department of Pathobiology & Diagnostic Investigation,College of Veterinary Medicine,Michigan State University, East Lansing, 48824, USA.; Park George, Department of Pathobiology & Diagnostic Investigation,College of Veterinary Medicine,Michigan State University, East Lansing, 48824, USA.; Deng Furong, Department of Occupational & Environmental Health Sciences,School of Public Health,Peking University, Beijing 100191, China.; Guo Xinbiao, Department of Occupational & Environmental Health Sciences,...
推荐引用方式 GB/T 7714	Wang Bin,Li Ning,Deng Furong,et al. Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents[J],2016,47:201-210.
APA	Wang Bin.,Li Ning.,Deng Furong.,Buglak Nicholas.,Park George.,...&Guo Xinbiao.(2016).Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents.Journal of Environmental Sciences,47,201-210.
MLA	Wang Bin,et al."Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents".Journal of Environmental Sciences 47(2016):201-210.