干旱区生态环境知识资源中心(Arid): Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert

Arid

	Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert
	Nan Zedong; Zhao Mingbo; Zeng Kewu; Tian Shuaihua; Wang Weinan; Jiang Yong; Tu Pengfei
来源期刊	Chinese Journal of Natural Medicines
ISSN	2095-6975
出版年	2016
卷号	14 期号:1 页码:61-65
英文摘要	In order to determine the chemical constituents of Cistanche deserticola cultured in Tarim desert, a systematically phytochemical investigation was carried out. The constituents were isolated by silica gel, Sephadex LH-20, MCI gel, ODS column chromatography, and semi-preparative HPLC. Their structures were determined on the basis of MS and NMR spectroscopic analyses, by chemical methods, and/or comparison with literature data. The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 mouse microglial cells. Nine iridoids were isolated and identified as cistadesertoside A (1), cistanin (2), cistachlorin (3), 6-deoxycatalpol (4), gluroside (5), kankanoside A (6), ajugol (7), bartsioside (8), and 8-epi-loganic acid (9). Compound 9 exhibited potent inhibition on the NO production with an IC_(50) value being 5.2 mumol·L~(-1), comparable to the positive control quercetin (4.3 mumol·L~(-1)). Compound 1 was a new iridoid, and compounds 5, 6, and 8 were isolated from this species for the first time.
英文关键词	Cistanche deserticola Iridoids Structure elucidation Anti-inflammatory activity
类型	Article
语种	英语
收录类别	CSCD
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:5625110
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/335601
作者单位	Nan Zedong, School of Pharmaceutical Sciences, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.; Zhao Mingbo, School of Pharmaceutical Sciences, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.; Zeng Kewu, School of Pharmaceutical Sciences, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.; Tian Shuaihua, School of Pharmaceutical Sciences, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.; Wang Weinan, School of Pharmaceutical Sciences, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.; Jiang Yong, School of Pharmaceutical Sciences, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.; Tu Pengfei, School of Pharmaceutical Sciences, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.
推荐引用方式 GB/T 7714	Nan Zedong,Zhao Mingbo,Zeng Kewu,et al. Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert[J],2016,14(1):61-65.
APA	Nan Zedong.,Zhao Mingbo.,Zeng Kewu.,Tian Shuaihua.,Wang Weinan.,...&Tu Pengfei.(2016).Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert.Chinese Journal of Natural Medicines,14(1),61-65.
MLA	Nan Zedong,et al."Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert".Chinese Journal of Natural Medicines 14.1(2016):61-65.