干旱区生态环境知识资源中心(Arid): Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

Arid

	Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus
	Xiang Jianfeng; Yin Qingfei; Chen Tian; Zhang Yang; Zhang Xiaoou; Wu Zheng; Zhang Shaofeng; Wang Haibin; Ge Junhui; Lu Xuhua; Yang Li; Chen Lingling
来源期刊	Cell Research
ISSN	1001-0602
出版年	2014
卷号	24 期号:5 页码:513-531
英文摘要	The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA), CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC. This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. These results reveal an important role of a previously unannotated lncRNA in gene regulation at the MYC locus.
英文关键词	CCAT1-L lncRNA super-enhancer chromatin looping MYC CTCF
类型	Article
语种	英语
开放获取类型	Other Gold, Green Published
收录类别	CSCD
WOS研究方向	Life Sciences & Biomedicine - Other Topics
CSCD记录号	CSCD:5141678
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/335357
作者单位	Xiang Jianfeng, Institute of Biochemistry and Cell Biology, State Key Laboratory of Molecular Biology.; Yin Qingfei, Institute of Biochemistry and Cell Biology, State Key Laboratory of Molecular Biology.; Chen Tian, Institute of Biochemistry and Cell Biology, State Key Laboratory of Molecular Biology.; Zhang Yang, Institute of Biochemistry and Cell Biology, State Key Laboratory of Molecular Biology.; Wu Zheng, Institute of Biochemistry and Cell Biology, State Key Laboratory of Molecular Biology.; Zhang Shaofeng, Institute of Biochemistry and Cell Biology, State Key Laboratory of Molecular Biology.; Chen Lingling, Institute of Biochemistry and Cell Biology, State Key Laboratory of Molecular Biology.; Zhang Xiaoou, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Key Laboratory of Computational Biology, Chinese Academy of Sciences, Shanghai 200031, China.; Yang Li, CAS-MPG Partner Institute for Computational Biol...
推荐引用方式 GB/T 7714	Xiang Jianfeng,Yin Qingfei,Chen Tian,et al. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus[J],2014,24(5):513-531.
APA	Xiang Jianfeng.,Yin Qingfei.,Chen Tian.,Zhang Yang.,Zhang Xiaoou.,...&Chen Lingling.(2014).Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus.Cell Research,24(5),513-531.
MLA	Xiang Jianfeng,et al."Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus".Cell Research 24.5(2014):513-531.