干旱区生态环境知识资源中心(Arid): New expression of bimodal phase distributions in direct-method phasing of protein single-wavelength anomalous diffraction data

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	New expression of bimodal phase distributions in direct-method phasing of protein single-wavelength anomalous diffraction data
	Zhang Tao; Gu Yuanxin; Zheng Chaode; Fan Haifu
来源期刊	Chinese Physics B
ISSN	1674-1056
出版年	2010
卷号	19 期号:8 页码:86102-
英文摘要	One of the essential points of the direct-method single-wavelength anomalous diffraction (SAD) phasing for proteins is to express the bimodal SAD phase distribution by the sum of two Gaussian functions peaked respectively at _h~'' + \|△h\| and _h~'' -\|△h\| The probability for △_h being positive (P+) can be derived based on the Cochran distribution in direct methods. Hence the SAD phase ambiguity can be resolved by multiplying the Gaussian function peaked at _h~'' + \|△h\| with P+ and multiplying the Gaussian function peaked at _h~" - \|△p_h\| with P_ (= 1 - P+). The direct-method SAD phasing has been proved powerful in breaking SAD phase ambiguities, in particular when anomalous-scattering signals are weak. However, the approximation of bimodal phase distributions by the sum of two Gaussian functions introduces considerable errors. In this paper we show that a much better approximation can be achieved by replacing the two Gaussian functions with two von Mises distributions. Test results showed that this leads to significant improvement on the efficiency of direct-method SAD-phasing.
英文关键词	direct methods single-wavelength anomalous diffraction OASIS program proteins
类型	Article
语种	英语
收录类别	CSCD
WOS研究方向	Physics
CSCD记录号	CSCD:3899859
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/335062
作者单位	Zhang Tao, Institute of Physics, Chinese Academy of Sciences, Beijing National Laboratory for Condensed Matter Physics;;Key Laboratory of Soft Matter Physics, Chinese Academy of Sciences, Beijing 100190, China.; Gu Yuanxin, Institute of Physics, Chinese Academy of Sciences, Beijing National Laboratory for Condensed Matter Physics;;Key Laboratory of Soft Matter Physics, Chinese Academy of Sciences, Beijing 100190, China.; Zheng Chaode, Institute of Physics, Chinese Academy of Sciences, Beijing National Laboratory for Condensed Matter Physics;;Key Laboratory of Soft Matter Physics, Chinese Academy of Sciences, Beijing 100190, China.; Fan Haifu, Institute of Physics, Chinese Academy of Sciences, Beijing National Laboratory for Condensed Matter Physics;;Key Laboratory of Soft Matter Physics, Chinese Academy of Sciences, Beijing 100190, China.
推荐引用方式 GB/T 7714	Zhang Tao,Gu Yuanxin,Zheng Chaode,et al. New expression of bimodal phase distributions in direct-method phasing of protein single-wavelength anomalous diffraction data[J],2010,19(8):86102-.
APA	Zhang Tao,Gu Yuanxin,Zheng Chaode,&Fan Haifu.(2010).New expression of bimodal phase distributions in direct-method phasing of protein single-wavelength anomalous diffraction data.Chinese Physics B,19(8),86102-.
MLA	Zhang Tao,et al."New expression of bimodal phase distributions in direct-method phasing of protein single-wavelength anomalous diffraction data".Chinese Physics B 19.8(2010):86102-.