干旱区生态环境知识资源中心(Arid): STUDY CYTOTOXICITY, ANTIBACTERIAL ACTIVITY, AND COMPOSITIONS BY FT-IR AND GC-MS FOR ORGANIC EXTRACT OF WHITE IRAQI DESERT TRUFFLE TIRMANIA NIVEA

Arid

	STUDY CYTOTOXICITY, ANTIBACTERIAL ACTIVITY, AND COMPOSITIONS BY FT-IR AND GC-MS FOR ORGANIC EXTRACT OF WHITE IRAQI DESERT TRUFFLE TIRMANIA NIVEA
	Hachim, Ahmad Khadem; Hateet, Rashid Rahim; Muhsin, Tawfik Muhammad
通讯作者	Hachim, AK
来源期刊	PERIODICO TCHE QUIMICA
ISSN	1806-0374
EISSN	2179-0302
出版年	2020
卷号	17 期号:36 页码:18-31
英文摘要	The purpose of the present work aimed at exploring the potential biochemical components and biological activities of an organic extract of the white truffle Tirmania nivea collected from the Iraqi desert, then test the organic extract against the Cytotoxicity on Human Larynx carcinoma cells and selected strains of pathogenic bacteria. Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrometry GC/MSS were used to analyze mycochemical compositions. The antibacterial activity and Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) was investigated using a disk diffusion agar method. The truffle extract's cytotoxicity effect against the larynx cell line (Hep-2) was assessed by the MTT assay (in vitro). FTIR results provided the presence of phenol, carboxylic acid, and alkane's functional group, The GC-MS analysis of T. nivea disclose the existence of nineteen compounds that can contribute to the pharmaceutical properties of the truffle. As for antibacterial activity result, A growth inhibition activity of truffle extract at (18-40 mm inhibition zones) against the tested pathogenic bacterial strains was detected, which minimum inhibitory concentration values ranged from 3.12 to 6.25 mg/mL for Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) Respectively. The results of cytotoxicity shown that the organic truffle extract exhibited a high inhibitory rate (52.685%) against cell line (Hep-2) at a concentration of 1.56 mu g/mL. In this work, the results showed that the organic extracts of T. nivea are very promising as cancer cytotoxicity and antibacterial agent for future medical applications.
英文关键词	Tirmania nivea Larynx carcinoma MTT assay Pathogenic bacteria Pharmaceutical properties
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000592996100002
WOS关键词	CHEMICAL-COMPOSITION ; TERFEZIA-CLAVERYI ; ANTIOXIDANT ; ANTICANCER ; MUSHROOMS ; PINOYI ; CHATIN ; FUNGI ; ACID ; OIL
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/334758
作者单位	[Hachim, Ahmad Khadem] Directorate Educ, Basrah, Iraq; [Hateet, Rashid Rahim] Univ Misan, Coll Sci, Dept Biol, Maysan, Iraq; [Muhsin, Tawfik Muhammad] Univ Basrah, Coll Educ Pure Sci, Dept Biol, Basrah, Iraq
推荐引用方式 GB/T 7714	Hachim, Ahmad Khadem,Hateet, Rashid Rahim,Muhsin, Tawfik Muhammad. STUDY CYTOTOXICITY, ANTIBACTERIAL ACTIVITY, AND COMPOSITIONS BY FT-IR AND GC-MS FOR ORGANIC EXTRACT OF WHITE IRAQI DESERT TRUFFLE TIRMANIA NIVEA[J],2020,17(36):18-31.
APA	Hachim, Ahmad Khadem,Hateet, Rashid Rahim,&Muhsin, Tawfik Muhammad.(2020).STUDY CYTOTOXICITY, ANTIBACTERIAL ACTIVITY, AND COMPOSITIONS BY FT-IR AND GC-MS FOR ORGANIC EXTRACT OF WHITE IRAQI DESERT TRUFFLE TIRMANIA NIVEA.PERIODICO TCHE QUIMICA,17(36),18-31.
MLA	Hachim, Ahmad Khadem,et al."STUDY CYTOTOXICITY, ANTIBACTERIAL ACTIVITY, AND COMPOSITIONS BY FT-IR AND GC-MS FOR ORGANIC EXTRACT OF WHITE IRAQI DESERT TRUFFLE TIRMANIA NIVEA".PERIODICO TCHE QUIMICA 17.36(2020):18-31.