干旱区生态环境知识资源中心(Arid): Pharmacodynamics of Secondary Metabolites Extracts of Some Plants from Cholistan Desert in Altering in Vitro Human Haematological Indices

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	Pharmacodynamics of Secondary Metabolites Extracts of Some Plants from Cholistan Desert in Altering in Vitro Human Haematological Indices
	Yasin, Ghulam; Anwer, Iqra; Majeed, Iqra; Sabir, Mubashrah; Mumtaz, Sundas; Mehmood, Amna
通讯作者	Yasin, G
来源期刊	INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH
ISSN	2250-1029
EISSN	2249-6084
出版年	2020
卷号	10 期号:2 页码:138-147
英文摘要	Background: The vegetation of deserts comprise of plants synthesizing secondary metabolites, which have phytopharmacological potential and provide a mechanism of secondary defense against stresses, pathogens, and herbivores. Secondary metabolites, when used by animals and human beings as food or medicine, also defend the individual against diseases. The trafficking of defense strategy of secondary metabolites can be judged by the health status of an individual when treated with plant resourced metabolites as food or medicine. Blood characteristics of humans determine the physiology and health status of the individual. So any change brought in blood by exposure to secondary metabolites can determine the importance of their transfer from plants to humans. Design: The extracts were mixed with human blood in a 1:4 ratio and were analyzed by using the Automated Hematology Analyzer machine for complete blood count tests (CBC). Data were statistically analyzed by using one way ANOVA (Analysis Of Variance). The level of statistical significance was set at (P < 0.05). Means were separated by Duncan's multiple range tests. Results: The results showed that leaves, stem, and flower ethanolic extracts significantly increased leukocyte, granulocyte, granulocyte count, HCT, and MCV while significantly decreased eosinophils, platelets, and RBC. On some of the parameters, different parts of the plant showed different effects on the same hematological parameter as leaves and stem significantly reduced the lymphocyte but flower caused an insignificant reduction. Leaves and stem resulted in a significant increase of monocyte and monocyte count but flower significantly and insignificantly reduced the monocyte and monocyte count, respectively. Leaves and flowers of the plant insignificantly decreased the HGB while stem caused a significant increase. A significant increase of the MCH was observed in the case of leaves and stem while flowers showed an insignificant increase. Leaves and flowers significantly decreased the MCHC and stem insignificantly decreased the MCHC.
英文关键词	Pharmacodynamics secondary metabolite Cholistan desert human hematological
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000586752400003
WOS关键词	DROUGHT STRESS ; ANTIOXIDANT ; VEGETATION ; FORMS ; WHEAT ; L.
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/334724
作者单位	[Yasin, Ghulam; Anwer, Iqra; Majeed, Iqra; Sabir, Mubashrah; Mumtaz, Sundas; Mehmood, Amna] Bahauddin Zakariya Univ, Dept Bot, Multan, Pakistan
推荐引用方式 GB/T 7714	Yasin, Ghulam,Anwer, Iqra,Majeed, Iqra,et al. Pharmacodynamics of Secondary Metabolites Extracts of Some Plants from Cholistan Desert in Altering in Vitro Human Haematological Indices[J],2020,10(2):138-147.
APA	Yasin, Ghulam,Anwer, Iqra,Majeed, Iqra,Sabir, Mubashrah,Mumtaz, Sundas,&Mehmood, Amna.(2020).Pharmacodynamics of Secondary Metabolites Extracts of Some Plants from Cholistan Desert in Altering in Vitro Human Haematological Indices.INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH,10(2),138-147.
MLA	Yasin, Ghulam,et al."Pharmacodynamics of Secondary Metabolites Extracts of Some Plants from Cholistan Desert in Altering in Vitro Human Haematological Indices".INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH 10.2(2020):138-147.