干旱区生态环境知识资源中心(Arid): Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells

Arid

DOI	10.2478/ebtj-2020-0012
	Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells
	Najjaa, Hanen; Abdelkarim, Ben Arfa; Doria, Enrico; Boubakri, Abdelbacett; Trabelsi, Najla; Falleh, Hanen; Tlili, Hajer; Neffati, Mohamed
通讯作者	Najjaa, H
来源期刊	EUROBIOTECH JOURNAL
EISSN	2564-615X
出版年	2020
卷号	4 期号:2 页码:104-112
英文摘要	Plants have been seen to possess the potential to be excellent biological matrices to serve as a basis for investigating the presence of promising therapeutic agents for cancer treatment. Several successful anti-cancer medicines - or their analogues nowadays in use are plant derived and many more are under clinical trials. Under current circumstances, the purpose of this work was to test aqueous and ethanolic extracts of five aromatic and medicinal plants from arid zones on some tumor cell lines. These plants, Cymbopogon schoenanthus (L.) Spreng, Crithmum maritimum (L.) Spreng, Hammada scoparia (Pomel) Iljin, Retama raetam (Forssk.) and Zizyphus lotus (L.) Desf., widely used in Tunisian ethnomedicine, were assessed for their phenolic compounds, antioxidants and anticancer activities in aqueous and ethanol extracts. Total polyphenols, flavonoid and tannin contents were determined colorimetrically and some of these molecules were identified using RP-HPLC. A significant difference on phenolic contents and composition were found among the investigated plants. Cymbopogon schoenanthus was the richest in phenolic compounds (approx. 72%) with quercetine-3-o-rhamnoside (approx. 33%) as main contributor. For all the tested plants, the highest antioxidant capacity was detected in the ethanolic extracts rather than in the aqueous ones. The highest antiproliferative potential was observed for the ethanolic extracts. Hammada scoparia, Retama raetam and Zizyphus lotus exhibited important antiproliferative effect that reached 67% at a 1% extract concentration. Taken together, the present study supports the potential development of chemotherapeutic agents from, at least, four of the five studied Tunisian ethnomedicinal plants.
英文关键词	Antioxidant capacity antiproliferative potential breast cancer phenolic compounds traditional medicinal plants
类型	Article
语种	英语
开放获取类型	DOAJ Gold, Green Published
收录类别	ESCI
WOS记录号	WOS:000528277900006
WOS关键词	ANTIOXIDANT ; L.
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/334321
作者单位	[Najjaa, Hanen; Abdelkarim, Ben Arfa; Boubakri, Abdelbacett; Tlili, Hajer; Neffati, Mohamed] Inst Reg Arides, Lab Ecosyst Pastoraux & Valorisat Plantes Spontan, Medenine 4119, Tunisia; [Doria, Enrico] Univ Pavia, Dept Biol & Biotechnol, Pavia, Italy; [Trabelsi, Najla; Falleh, Hanen] Ctr Biotechnol Borj Cedria, Lab Olive Biotechnol, Borj Cedria, Tunisia
推荐引用方式 GB/T 7714	Najjaa, Hanen,Abdelkarim, Ben Arfa,Doria, Enrico,et al. Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells[J],2020,4(2):104-112.
APA	Najjaa, Hanen.,Abdelkarim, Ben Arfa.,Doria, Enrico.,Boubakri, Abdelbacett.,Trabelsi, Najla.,...&Neffati, Mohamed.(2020).Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells.EUROBIOTECH JOURNAL,4(2),104-112.
MLA	Najjaa, Hanen,et al."Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells".EUROBIOTECH JOURNAL 4.2(2020):104-112.