干旱区生态环境知识资源中心(Arid): Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma

Arid

DOI	10.21608/ajnsa.2019.66500
	Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma
	El-Sonbaty, S. M.; Hassan, A. A.
通讯作者	Hassan, AA
来源期刊	ARAB JOURNAL OF NUCLEAR SCIENCES AND APPLICATIONS
ISSN	1110-0451
出版年	2020
卷号	53 期号:1 页码:234-242
英文摘要	For many decades the terrestrial plants are represent an infinitive source of bioactive substances as well as pharmaceutical components which play a main role in the discovering ,developing and manufacturing of anticancer and antibiotic drugs. Solenostemmaargel is a desert plant widely used in Arabic countries as antispasmodic, anti-inflammatory and anti-rheumatic agent. It also has anti-tumor activity. Aim: the present study was oriented to investigatethe hepato-protective effect of fermentedSolenostemmaargelleave extract (100amg/kg b.wt) and/or low dose gamma-radiation (0.5Gy) againsthepatocellular carcinoma (HCC)developedin rats by injection of diethylnitrosamine. Results: the data obtained revealed that thepro-apoptotic agents (caspase 3 and cytochrome c) undergoes significant elevation in HCC rats received plant extract and/or gamma-radiation compared to HCC rats.While,the vascular endothelial growth factor (VEGF), hypoxia inducible factor-alpha (HIF-alpha)and monocytichemotactic protein-1(MCP-1) were significantly decreased. Also, the activity of cyclooxygenase-2 (COX-2) was significantly decreased. Moreover, the histopathological analysis revealed that a mild improvement. In conclusion, the improvement emerged in HCC rats could be attributed to the potency of extract and/or gamma- radiation by induce apoptosis and reduce angiogenesis.
英文关键词	Fermented Solenostemmaargel Extract Low Dose gamma-Radiation HCC Diethylnitrosamine
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	ESCI
WOS记录号	WOS:000508233400024
WOS关键词	OXIDATIVE STRESS ; EXPRESSION ; CANCER ; VEGF ; HEPATOCARCINOGENESIS ; GROWTH
WOS类目	Nuclear Science & Technology
WOS研究方向	Nuclear Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/334204
作者单位	[El-Sonbaty, S. M.] Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Radiat Microbiol, Cairo, Egypt; [Hassan, A. A.] Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Radiat Biol, Cairo, Egypt
推荐引用方式 GB/T 7714	El-Sonbaty, S. M.,Hassan, A. A.. Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma[J],2020,53(1):234-242.
APA	El-Sonbaty, S. M.,&Hassan, A. A..(2020).Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma.ARAB JOURNAL OF NUCLEAR SCIENCES AND APPLICATIONS,53(1),234-242.
MLA	El-Sonbaty, S. M.,et al."Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma".ARAB JOURNAL OF NUCLEAR SCIENCES AND APPLICATIONS 53.1(2020):234-242.