干旱区生态环境知识资源中心(Arid): Determination of streptomycin and dihydrostreptomycin residues in honey by hydrophilic interaction liquid chromatography-tandem mass spectrometry

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DOI	10.3724/SP.J.1123.2019.01029
	Determination of streptomycin and dihydrostreptomycin residues in honey by hydrophilic interaction liquid chromatography-tandem mass spectrometry
	Wei Lili; Xue Xia; Liu Yanming; Sun Lizhen; Cheng Zhi; Su Shufang; Zhao Yin
通讯作者	Xue, X
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2019
卷号	37 期号:7 页码:735-741
英文摘要	An analytical method was developed for the determination of streptomycin and dihydrostreptomycin in honey using hydrophilic interaction liquid chromatography. tandem mass spectrometry (HILIC-MS/MS). The streptomycin and dihydrostreptomycin residues in the test samples were extracted with 20 g/L trichloroacetic acid aqueous solution (including 50 mmol/L phosphate, pH 6.8) and cleaned on an Oasis HLB solid phase extraction column. The products were separated on a SIELC Obelisc R column with gradient elution using 0.5% (v/v) formic acid aqueous solution and acetonitrile as mobile phases. Streptomycin and dihydrostreptomycin were detected by liquid chromatography.tandem mass spectrometry in the positive ion mode using the external standard method. Under the optimal conditions, streptomycin and dihydro. streptomycin showed good linearity (r > 0.99) in the range of 2.5-100 mu g/L. The LOD and LOQ of the method was 2.0 mu g/kg and 5.0 mu g/kg, respectively. The spiked recoveries of the ana. lytes from blank honey samples at the three levels of 5.0, 20.0 and 100.0 mu g/kg were in the range of 86.9%-113.2% with the relative standard deviations less than 10%. With the advantages of convenience, rapidity, sensitivity and good repeatability, the method is suitable for the detection of streptomycin and dihydrostreptomycin in honey.
英文关键词	hydrophilic interaction chromatography-tandem mass spectrometry (HILIC-MS/MS) solid phase extraction (SPE) streptomycin (STR) dihydrostreptomycin (DHSTR) honey
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000502577400008
WOS关键词	MOLECULARLY IMPRINTED POLYMERS ; AMINOGLYCOSIDES ; ANTIBIOTICS ; EXTRACTION ; MILK
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333981
作者单位	[Wei Lili; Xue Xia; Liu Yanming; Sun Lizhen; Cheng Zhi; Su Shufang; Zhao Yin] Shandong Inst Food & Drug Control, Jinan 250101, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wei Lili,Xue Xia,Liu Yanming,et al. Determination of streptomycin and dihydrostreptomycin residues in honey by hydrophilic interaction liquid chromatography-tandem mass spectrometry[J],2019,37(7):735-741.
APA	Wei Lili.,Xue Xia.,Liu Yanming.,Sun Lizhen.,Cheng Zhi.,...&Zhao Yin.(2019).Determination of streptomycin and dihydrostreptomycin residues in honey by hydrophilic interaction liquid chromatography-tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,37(7),735-741.
MLA	Wei Lili,et al."Determination of streptomycin and dihydrostreptomycin residues in honey by hydrophilic interaction liquid chromatography-tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 37.7(2019):735-741.