干旱区生态环境知识资源中心(Arid): Phytochemical Analysis and Antifungal Bioactivity of Pulicaria undulata (L.) Methanolic Extract and Essential Oil

Arid

DOI	10.21608/ejbo.2019.12259.1308
	Phytochemical Analysis and Antifungal Bioactivity of Pulicaria undulata (L.) Methanolic Extract and Essential Oil
	Helal, Nesma Maher; Ibrahim, Nevin A.; Khattab, Hemmat
通讯作者	Helal, NM
来源期刊	EGYPTIAN JOURNAL OF BOTANY
ISSN	0375-9237
EISSN	2357-0350
出版年	2019
卷号	59 期号:3 页码:827-844
英文摘要	PULICARIA UNDULATA is one of the aromatic annual herbs used in folk medicine in Egypt. The aerial parts of P. undulata plants were collected from the Red sea coastal desert during the flowering stage and used for phytochemical analysis. It was revealed that P. undulata aerial portions contain phenols, flavonoids terpenoids, saponins, alkaloids, glucosinolates and cardiac glycosides highlighting its participation in drug development and using as an alternative strategy to the harmful synthetic fungicides. The greater accumulation of the bioactive compounds in the methanolic extract was comparable with its higher antioxidant capacity and IC50 value as compared with those of the petroleum ether extract. The GC-MS analysis revealed the occurrence of ten bioactive phytocomponents including cyclotrisiloxane, hexamethyl-, cyclotetrasiloxane, octamethyl-, cyclopentasiloxane, decamethyl, dodecanoic acid, methyl ester, tetrafluorophthalonitrile, gamma-Sitosterol, nonacosane, 4,4,6a,6b,8a,11,11,14b-Octamethyl,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-octadecahydro-2H-picen-3-one, thiazolo[4,5-f]quinoline and 7-methyl-. In addition, the methanolic extract exhibited antifungal activity against the investigated six pathogenic fungal strains: Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Microsporum canis, Microsporum boulardii and Trichophyton mentagrophytes. Based on the values of the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC), the methanolic extract has demonstrated a fungicidal effect on M. boulardii IFM 56403, T. mentagrophytes AUMC 11661, M. canis AUMC 11663, and C. albicans AUMC 9142. The cytotoxicity evaluation of the methanolic extract showed safe levels in case of these four fungal strains. The petroleum ether extract, inhibited the tested fungi but with lower efficiency. Our results suggest the promising antifungal activity of P. undulata on medically important fungi.
英文关键词	Pulucaria undulata Phytochemicals GC-MS Antifungals
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	ESCI
WOS记录号	WOS:000499650100021
WOS关键词	TRADITIONAL MEDICINE ; ANTIMICROBIAL ACTIVITY ; SECONDARY METABOLITES ; CHEMICAL-COMPOSITION ; IN-VITRO ; INFECTIONS ; PLANTS ; GROWTH ; ANTIBACTERIAL ; ASSAY
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333947
作者单位	[Helal, Nesma Maher; Khattab, Hemmat] Ain Shams Univ, Fac Sci, Bot Dept, Cairo, Egypt; [Ibrahim, Nevin A.] Ain Shams Univ, Fac Sci, Microbiol Dept, Cairo, Egypt
推荐引用方式 GB/T 7714	Helal, Nesma Maher,Ibrahim, Nevin A.,Khattab, Hemmat. Phytochemical Analysis and Antifungal Bioactivity of Pulicaria undulata (L.) Methanolic Extract and Essential Oil[J],2019,59(3):827-844.
APA	Helal, Nesma Maher,Ibrahim, Nevin A.,&Khattab, Hemmat.(2019).Phytochemical Analysis and Antifungal Bioactivity of Pulicaria undulata (L.) Methanolic Extract and Essential Oil.EGYPTIAN JOURNAL OF BOTANY,59(3),827-844.
MLA	Helal, Nesma Maher,et al."Phytochemical Analysis and Antifungal Bioactivity of Pulicaria undulata (L.) Methanolic Extract and Essential Oil".EGYPTIAN JOURNAL OF BOTANY 59.3(2019):827-844.