干旱区生态环境知识资源中心(Arid): Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?

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DOI	10.1155/2019/5283948
	Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?
	Sivalingam, Periyasamy; Hong, Kui; Pote, John; Prabakar, Kandasamy
通讯作者	Sivalingam, P
来源期刊	INTERNATIONAL JOURNAL OF MICROBIOLOGY
ISSN	1687-918X
EISSN	1687-9198
出版年	2019
卷号	2019
英文摘要	Antimicrobial resistance (AR) is recognized as one of the greatest threats to public health and in global concern. Consequently, the increased morbidity and mortality, which are associated with multidrug resistance bacteria, urgently require the discovery of novel and more efficient drugs. Conversely, cancer is a growing complex human disease that demands new drugs with no or fewer side effects. Most of the drugs currently used in the health care systems were of Streptomyces origin or their synthetic forms. Natural product researches from Streptomyces have been genuinely spectacular over the recent years from extreme environments. It is because of technical advances in isolation, fermentation, spectroscopy, and genomic studies which led to the efficient recovering of Streptomyces and their new chemical compounds with distinct activities. Expanding the use of the last line of antibiotics and demand for new drugs will continue to play an essential role for the potent Streptomyces from previously unexplored environmental sources. In this context, deep-sea, desert, cryo, and volcanic environments have proven to be a unique habitat of more extreme, and of their adaptation to extreme living, environments attribute to novel antibiotics. Extreme Streptomyces have been an excellent source of a new class of compounds which include alkaloids, angucycline, macrolide, and peptides. This review covers novel drug leads with antibacterial and cytotoxic activities isolated from deep-sea, desert, cryo, and volcanic environment Streptomyces from 2009 to 2019. The structure and chemical classes of the compounds, their relevant bioactivities, and the sources of organisms are presented.
类型	Review
语种	英语
开放获取类型	Other Gold, Green Published
收录类别	ESCI
WOS记录号	WOS:000475602400001
WOS关键词	BIOSYNTHETIC GENE-CLUSTER ; HYPER-ARID SOILS ; DEEP-SEA ; SP NOV. ; ATACAMA DESERT ; A-D ; SPIROTETRONATE ANTIBIOTICS ; SECONDARY METABOLITES ; BISINDOLE ALKALOIDS ; GENOME SEQUENCE
WOS类目	Microbiology
WOS研究方向	Microbiology
Scopus学科分类	Univ Geneva, Inst Environm Sci, Fac Sci, Sch Earth & Environm Sci,Uni Carl Vogt, 66 Blvd Carl Vogt, CH-1211 Geneva 4, Switzerland. ; Prabakar, K
CSCD记录号	CSCD:Jamal Mohamed Coll, Postgrad & Res Dept Zool, Tiruchirappalli 620020, Tamil Nadu, India.
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333690
作者单位	[Sivalingam, Periyasamy; Pote, John] Univ Geneva, Dept FA Forel Environm & Aquat Sci, Fac Sci, Sch Earth & Environm Sci,Uni Carl Vogt, 66 Blvd Carl Vogt, CH-1211 Geneva 4, Switzerland; [Sivalingam, Periyasamy; Pote, John] Univ Geneva, Inst Environm Sci, Fac Sci, Sch Earth & Environm Sci,Uni Carl Vogt, 66 Blvd Carl Vogt, CH-1211 Geneva 4, Switzerland; [Hong, Kui] Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China; [Prabakar, Kandasamy] Jamal Mohamed Coll, Postgrad & Res Dept Zool, Tiruchirappalli 620020, Tamil Nadu, India
推荐引用方式 GB/T 7714	Sivalingam, Periyasamy,Hong, Kui,Pote, John,et al. Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?[J],2019,2019.
APA	Sivalingam, Periyasamy,Hong, Kui,Pote, John,&Prabakar, Kandasamy.(2019).Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?.INTERNATIONAL JOURNAL OF MICROBIOLOGY,2019.
MLA	Sivalingam, Periyasamy,et al."Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?".INTERNATIONAL JOURNAL OF MICROBIOLOGY 2019(2019).