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| DOI | 10.3390/jdb7020009 |
| Hedgehog Signaling and Embryonic Craniofacial Disorders | |
| Abramyan, John | |
| 通讯作者 | Abramyan, J |
| 来源期刊 | JOURNAL OF DEVELOPMENTAL BIOLOGY
 |
| ISSN | 2221-3759 |
| 出版年 | 2019 |
| 卷号 | 7期号:2 |
| 英文摘要 | Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh). Of the three, Shh has the broadest range of functions both in the face and elsewhere in the embryo, while Ihh and Dhh play more limited roles. The Hedgehog pathway is instrumental from the period of prechordal plate formation early in the embryo, until the fusion of the lip and secondary palate, which complete the major patterning events of the face. Disruption of Hedgehog signaling results in an array of developmental disorders in the face, ranging from minor alterations in the distance between the eyes to more serious conditions such as severe clefting of the lip and palate. Despite its critical role, Hedgehog signaling seems to be disrupted through a number of mechanisms that may either be direct, as in mutation of a downstream target of the Hedgehog ligand, or indirect, such as mutation in a ciliary protein that is otherwise seemingly unrelated to the Hedgehog pathway. A number of teratogens such as alcohol, statins and steroidal alkaloids also disrupt key aspects of Hedgehog signal transduction, leading to developmental defects that are similar, if not identical, to those of Hedgehog pathway mutations. The aim of this review is to highlight the variety of roles that Hedgehog signaling plays in developmental disorders of the vertebrate face. |
| 英文关键词 | Hedgehog craniofacial Shh Ihh holoprosencephaly ciliopathy |
| 类型 | Review |
| 语种 | 英语 |
| 开放获取类型 | Other Gold, Green Published |
| 收录类别 | ESCI |
| WOS记录号 | WOS:000474936900002 |
| WOS关键词 | FETAL ALCOHOL SYNDROME ; NEURAL CREST CELLS ; EPITHELIAL-MESENCHYMAL INTERACTIONS ; CHOLESTEROL-MODIFIED HEDGEHOG ; PROTEIN-KINASE-A ; SONIC-HEDGEHOG ; INTRAFLAGELLAR TRANSPORT ; INDIAN HEDGEHOG ; ETHANOL EXPOSURE ; FLOOR PLATE |
| WOS类目 | Developmental Biology |
| WOS研究方向 | Developmental Biology |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/333674 |
| 作者单位 | [Abramyan, John] Univ Michigan Dearborn, Dept Nat Sci, Dearborn, MI 48128 USA |
| 推荐引用方式 GB/T 7714 | Abramyan, John. Hedgehog Signaling and Embryonic Craniofacial Disorders[J],2019,7(2). |
| APA | Abramyan, John.(2019).Hedgehog Signaling and Embryonic Craniofacial Disorders.JOURNAL OF DEVELOPMENTAL BIOLOGY,7(2). |
| MLA | Abramyan, John."Hedgehog Signaling and Embryonic Craniofacial Disorders".JOURNAL OF DEVELOPMENTAL BIOLOGY 7.2(2019). |
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