干旱区生态环境知识资源中心(Arid): Determination of Ceftiofur Residues by Simple Solid Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry in Eel, Flatfish, and Shrimp

Arid

DOI	10.5478/MSL.2019.10.2.43
	Determination of Ceftiofur Residues by Simple Solid Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry in Eel, Flatfish, and Shrimp
	Kim, Joohye; Shin, Dasom; Kang, Hui-Seung; Lee, Eunhye; Choi, Soo Yeon; Lee, Hee-Seok; Cho, Byung-Hoon; Lee, Kang-Bong; Jeong, Jiyoon
通讯作者	Kang, HS
来源期刊	MASS SPECTROMETRY LETTERS
ISSN	2233-4203
EISSN	2093-8950
出版年	2019
卷号	10 期号:2 页码:43-49
英文摘要	The aim of this study was conducted to develop an analytical method to determine the concentration of ceftiofur residue in eel, flatfish, and shrimp. For derivatization and extraction, the sample was hydrolyzed with dithioerythritol to produce desfuroylceftiofur, which was then derivatized by iodoacetamide to obtain desfuroylceftiofur acetamide. For purification, the process of solid phase extraction (Oasis HLB) was used. The target analytes were confirmed and quantified in C 18 column using liquid chromatography-tandem mass spectrometry with 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B) as the mobile phase. The linearity of the standard calibration curve was confirmed by a correlation coefficient, r(2) > 0.99. The limit of quantification for ceftiofur was 0.002 mg/kg; the accuracy (expressed as the average recoveries) was 80.6-105%; the precision (expressed as the coefficient of variation) was below 6.3% at 0.015, 0.03, and 0.06 mg/kg. The validated method demonstrated high accuracy and acceptable sensitivity to meet the Codex guideline requirements. The developed method was tested using market samples. As a results, ceftiofur was detected in one sample. Therefore, it can be applied to the analysis of ceftiofur residues in fishery products.
英文关键词	ceftiofur residue analytical method fish shrimp LC-MS/MS
类型	Article
语种	英语
开放获取类型	DOAJ Gold
收录类别	ESCI
WOS记录号	WOS:000474464900001
WOS关键词	METABOLITE DESFUROYLCEFTIOFUR ; FISHERY PRODUCTS ; PLASMA ; DRUGS ; MILK
WOS类目	Spectroscopy
WOS研究方向	Spectroscopy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333665
作者单位	[Kim, Joohye; Shin, Dasom; Kang, Hui-Seung; Choi, Soo Yeon; Cho, Byung-Hoon; Lee, Kang-Bong; Jeong, Jiyoon] Natl Inst Food & Drug Safety Evaluat, Pesticide & Vet Drug Residues Div, Osong 363700, Chungcheongbuk, South Korea; [Lee, Eunhye] Minist Food & Drug Safety, Ctr Food & Drug Anal, Busan Reg Off, Food & Drug Adm, Cheongju, Chungcheongbuk, South Korea; [Lee, Hee-Seok] Natl Inst Food & Drug Safety Evaluat, Food Safety Risk Assessment Div, Osong 361709, Chungcheongbuk, South Korea
推荐引用方式 GB/T 7714	Kim, Joohye,Shin, Dasom,Kang, Hui-Seung,et al. Determination of Ceftiofur Residues by Simple Solid Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry in Eel, Flatfish, and Shrimp[J],2019,10(2):43-49.
APA	Kim, Joohye.,Shin, Dasom.,Kang, Hui-Seung.,Lee, Eunhye.,Choi, Soo Yeon.,...&Jeong, Jiyoon.(2019).Determination of Ceftiofur Residues by Simple Solid Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry in Eel, Flatfish, and Shrimp.MASS SPECTROMETRY LETTERS,10(2),43-49.
MLA	Kim, Joohye,et al."Determination of Ceftiofur Residues by Simple Solid Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry in Eel, Flatfish, and Shrimp".MASS SPECTROMETRY LETTERS 10.2(2019):43-49.