干旱区生态环境知识资源中心(Arid): Evaluation of Antidiabetic Potentiality of Truffles and Balanites Aegyptiaca among Streptozotocin Induced Diabetic Rats

Arid

	Evaluation of Antidiabetic Potentiality of Truffles and Balanites Aegyptiaca among Streptozotocin Induced Diabetic Rats
	Abdel-Mageed, Ahmad M.; Osman, Ahmed Kamal Eldin; Awad, Nabil S.; Abdein, Mohamed A.
通讯作者	Abdel-Mageed, AM
来源期刊	INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES
ISSN	2277-3657
出版年	2019
卷号	8 期号:1 页码:36-44
英文摘要	The potential application of Truffle (Terfeziaceae) and Desert Date tree (Balanites aegyptiaca) for modulating the diabetes mellitus related symptoms has gained much interest. However, less firm evidence has come from data to increase the understanding of the mechanism by which Truffle and Balanites protect pancreatic beta-cells. The present study aimed to evaluate the effect of methanolic extract of Truffle and Balanites aegyptiaca on the fasting blood glucose (FBG) level; the changes in pancreatic histology as well as the changes in iNOS and IL-1 beta genes expression level among STZ induced diabetic rats which might help in better clarification of possible mechanisms beside the beneficial effects of the studied plants on diabetes. The elevation of the FBG level, pathological pancreatic changes and the level of both IL-1 beta and iNOS gene expressions in diabetic rats were observed in comparison with negative control rats. This increase was declined significantly due to the administration of Truffle and Balanites extracts. All of the studied parameters did not completely reverse to the normal levels as compared with negative control rats. The obtained results concluded that the beneficial effect of Truffle and Balanites aegyptiaca on STZ-induced diabetes was at least partly due to the reduction of IL-1 beta and iNOS gene over the expression which can have a protective effect on beta cell.
英文关键词	Diabetes Rats Truffles Balanites Aegyptiaca IL-1 beta iNOS
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000466799800004
WOS关键词	FACTOR-KAPPA-B ; GENE-EXPRESSION ; ANTIOXIDANT ; EXTRACT ; CELLS ; HYPERGLYCEMIA ; MUSHROOMS ; ACTIVATION ; IL-1-BETA ; APOPTOSIS
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
Scopus学科分类	Menia Univ, Fac Sci, Zool Dept, Al Minya 61519, Egypt.
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333525
作者单位	[Abdel-Mageed, Ahmad M.; Abdein, Mohamed A.] Northern Border Univ, Fac Arts & Sci, Biol Dept, Rafha 91911, Saudi Arabia; [Abdel-Mageed, Ahmad M.] Menia Univ, Fac Sci, Zool Dept, Al Minya 61519, Egypt; [Osman, Ahmed Kamal Eldin] Northern Border Univ, Fac Sci, Biol Dept, Ar Ar 91431, Saudi Arabia; [Osman, Ahmed Kamal Eldin] South Valley Univ, Fac Sci, Bot Dept, Qena 83523, Egypt; [Awad, Nabil S.] Aswan Univ, Fac Agr & Nat Resources, Dept Genet, Aswan 81528, Egypt; [Awad, Nabil S.] Misr Univ Sci & Technol, Coll Biotechnol, Giza 12563, Egypt
推荐引用方式 GB/T 7714	Abdel-Mageed, Ahmad M.,Osman, Ahmed Kamal Eldin,Awad, Nabil S.,et al. Evaluation of Antidiabetic Potentiality of Truffles and Balanites Aegyptiaca among Streptozotocin Induced Diabetic Rats[J],2019,8(1):36-44.
APA	Abdel-Mageed, Ahmad M.,Osman, Ahmed Kamal Eldin,Awad, Nabil S.,&Abdein, Mohamed A..(2019).Evaluation of Antidiabetic Potentiality of Truffles and Balanites Aegyptiaca among Streptozotocin Induced Diabetic Rats.INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES,8(1),36-44.
MLA	Abdel-Mageed, Ahmad M.,et al."Evaluation of Antidiabetic Potentiality of Truffles and Balanites Aegyptiaca among Streptozotocin Induced Diabetic Rats".INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES 8.1(2019):36-44.