干旱区生态环境知识资源中心(Arid): The emulsion made with essential oil and aromatic water from Oliveria decumbens protects murine macrophages from LPS-induced oxidation and exerts relevant radical scavenging activities

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DOI	10.1016/j.bcab.2019.01.015
	The emulsion made with essential oil and aromatic water from Oliveria decumbens protects murine macrophages from LPS-induced oxidation and exerts relevant radical scavenging activities
	Karami, Akbar; Kavoosi, Gholamreza; Maggi, Filippo
通讯作者	Karami, A
来源期刊	BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
ISSN	1878-8181
出版年	2019
卷号	17 页码:538-544
英文摘要	Oliveria decumbens Vent., is an endemic plant of Iran belonging to the Apiaceae family, where it grows in the arid southeastern regions. In the traditional medicine, it is used in cases of indigestion, diarrhea, abdominal pain and fever. An nanoemulsion including polysorbate (100 mu g/mL), Oliveria decumbens essential oil (OEO, 1 mL) and O. decumbens aromatic water (OAW, 100 mL) was prepared. The radical scavenging and antioxidant capacity of OEO-OAW emulsion was investigated in lipopolysaccharide (LPS)-stimulated murine macrophages. The reduction of nitric oxide (NO), intracellular reactive oxygen species (ROS), and thiobarbitoric acid reactive substances (TBARS) at non-cytotoxic concentrations (< 3000 ng/mL) of OEO-OAW was determined. The main components of OEO were thymol (25.5%), carvacrol (23.1%), p-cymene (22.1%) and gamma-terpinene (17.8%). The emulsion exhibited 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH), 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical (ABTS), superoxide radical (O-2), hydrogen peroxide (H2O2), hydroxyl radical (HO), NO, nitrite (NO2) and malondialdehyde (MDA) scavenging effects as well as lipid oxidation inhibition at low concentrations (20-200 mu g/mL). In addition, at lower doses (1000-3000 ng/mL) it strongly reduced formation of NO, ROS and TBARS in LPS-stimulated macrophages. Taken together, our outcomes corroborate the antioxidant properties of O. decumbens formulation and provide new insights into the industrial and pharmacological properties of OEO-OAW.
英文关键词	Oliveria decumbens Essential oil Emulsion Radical scavenging Lipid peroxidation Macrophages Nitric oxide
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000458427900070
WOS关键词	NITRIC-OXIDE PRODUCTION ; ANTIOXIDANT ACTIVITY ; LIPID-PEROXIDATION ; HYDROGEN-PEROXIDE ; IN-VITRO ; EXTRACTION ; STRESS ; OXYGEN ; MECHANISMS ; FOOD
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333412
作者单位	[Karami, Akbar] Shiraz Univ, Fac Agr, Dept Hort Sci, Shiraz, Iran; [Kavoosi, Gholamreza] Shiraz Univ, Inst Biotechnol, Shiraz, Iran; [Maggi, Filippo] Univ Camerino, Sch Pharm, Camerino, Italy
推荐引用方式 GB/T 7714	Karami, Akbar,Kavoosi, Gholamreza,Maggi, Filippo. The emulsion made with essential oil and aromatic water from Oliveria decumbens protects murine macrophages from LPS-induced oxidation and exerts relevant radical scavenging activities[J],2019,17:538-544.
APA	Karami, Akbar,Kavoosi, Gholamreza,&Maggi, Filippo.(2019).The emulsion made with essential oil and aromatic water from Oliveria decumbens protects murine macrophages from LPS-induced oxidation and exerts relevant radical scavenging activities.BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY,17,538-544.
MLA	Karami, Akbar,et al."The emulsion made with essential oil and aromatic water from Oliveria decumbens protects murine macrophages from LPS-induced oxidation and exerts relevant radical scavenging activities".BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY 17(2019):538-544.