干旱区生态环境知识资源中心(Arid): Qualitative determination of toxic pyrrolizidine alkaloids in Trichodesma indicum: A prevalent ethnomedicine of Northern Pakistan

Arid

DOI	10.5455/jcmr.20180711060306
	Qualitative determination of toxic pyrrolizidine alkaloids in Trichodesma indicum: A prevalent ethnomedicine of Northern Pakistan
	Ahmad, Latif; He, Yi; Semotiuk, Andrew J.; Liu, Quan-Ru
通讯作者	Liu, QR
来源期刊	JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH
ISSN	2146-8397
EISSN	2577-5669
出版年	2018
卷号	9 期号:1 页码:11-23
英文摘要	Aim/Background: Trichodesma indicum (L.) Lehm. is a prominent medicinal plant in Pakistan. Various indigenous Pakistani communities use this plant orally to treat various human ailments. The present study is carried out with the aim to investigate the leaves of T. indicum for the presence or absence of toxic pyrrolizidine alkaloids (PAs). If these alkaloids are found, then the plant should be used with more precaution. Materials and Methods: For this, the dried leaf samples of T. indicum were collected from Northern Pakistan and brought to Beijing Normal University for further experimentation. Furthermore, to collect literature on the medicinal uses of T. indicum, we searched the scientific databases of PubMed, Google Scholar, and Scopus. In the laboratory, T. indicum was investigated for PAs by using high-performance liquid chromatography (HPLC)-ultraviolet. Results: The literature survey shows that the species is used for medicinal purposes throughout Pakistan. The result of HPLC fingerprint analysis showed that leaves were PA positive and out of five PA standards, four were detected, namely, (1) supinine, (2) europine, (3) heliotrine, and (5) echimidine. Conclusion: To the best of our knowledge, the present study reports, for the first time, the presence of unsaturated PAs in the leaves of T. indicum. Given this, we suggest that the plant should be used with more caution and should follow the rule defined by the German Federal Institute for Risk Assessment which requires that the exposure to unsaturated PAs from food should be as low as possible which is a daily intake of 0.007 mu g PAs kg(-1) for human's body weight.
英文关键词	Trichodesma indicum ethnomedicine pyrrolizidine alkaloids (PAs) toxicity Pakistan HPLC
类型	Article
语种	英语
开放获取类型	DOAJ Gold
收录类别	ESCI
WOS记录号	WOS:000454982900002
WOS关键词	JAMMU-AND-KASHMIR ; HEPATIC VENOOCCLUSIVE DISEASE ; HILLS NATIONAL-PARK ; MEDICINAL-PLANTS ; INDIGENOUS KNOWLEDGE ; FLORISTIC DIVERSITY ; ETHNOBOTANICAL USES ; NARA DESERT ; N-OXIDES ; DISTRICT
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
来源机构	北京师范大学
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333194
作者单位	[Ahmad, Latif; He, Yi; Liu, Quan-Ru] Beijing Normal Univ, Coll Life Sci, Beijing, Peoples R China; [Semotiuk, Andrew J.] Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA
推荐引用方式 GB/T 7714	Ahmad, Latif,He, Yi,Semotiuk, Andrew J.,et al. Qualitative determination of toxic pyrrolizidine alkaloids in Trichodesma indicum: A prevalent ethnomedicine of Northern Pakistan[J]. 北京师范大学,2018,9(1):11-23.
APA	Ahmad, Latif,He, Yi,Semotiuk, Andrew J.,&Liu, Quan-Ru.(2018).Qualitative determination of toxic pyrrolizidine alkaloids in Trichodesma indicum: A prevalent ethnomedicine of Northern Pakistan.JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH,9(1),11-23.
MLA	Ahmad, Latif,et al."Qualitative determination of toxic pyrrolizidine alkaloids in Trichodesma indicum: A prevalent ethnomedicine of Northern Pakistan".JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH 9.1(2018):11-23.