干旱区生态环境知识资源中心(Arid): Nevada desert dust with heavy metals suppresses IgM antibody production

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DOI	10.1016/j.toxrep.2018.01.006
	Nevada desert dust with heavy metals suppresses IgM antibody production
	Keil, Deborah E.; Buck, Brenda; Goossens, Dirk; McLaurin, Brett; Murphy, Lacey; Leetham-Spencer, Mallory; Teng, Yuanxin; Pollard, James; Gerads, Russell; DeWitt, Jamie C.
通讯作者	DeWitt, JC
来源期刊	TOXICOLOGY REPORTS
ISSN	2214-7500
出版年	2018
卷号	5 页码:258-269
英文摘要	Systemic health effects from exposure to a complex natural dust containing heavy metals from the Nellis Dunes Recreation Area (NDRA) near Las Vegas, NV, were evaluated. Several toxicological parameters were examined following lung exposure to emissive dust from three geologic sediment types heavily used for recreational offroad activities: yellow sand very rich in arsenic (termed CBN 5); a shallow cover of loose dune sand overlying a gravelly subsoil bordering dune fields (termed CBN 6); and brown claystone and siltstone (termed CBN 7). Adult female B6C3F1 mice were exposed by oropharyngeal administration to these three types of geogenic dusts at 0.01-100 mg of dust/kg of body weight, once per week for four weeks. The median grain sizes were 4.6, 3.1, and 4.4 mu m, for CBN 5, 6, and 7, respectively. Each type of dust contained quantifiable amounts of aluminum, vanadium, chromium, manganese, iron, cobalt, copper, zinc, arsenic, strontium, cesium, lead, uranium, and others. Descriptive markers of immunotoxicity, neurotoxicity, hematology, and clinical chemistry parameters were assessed. Notable among all three CBN units was a systemic, dose-responsive decrease in antigen-specific IgM antibody responses. Geogenic dust from CBN 5 produced more than a 70% suppression in IgM responses, establishing a lowest adverse effect level (LOAEL) of 0.01 mg/kg. A suppression in IgM responses and a corresponding increase in serum creatinine determined a LOAEL of 0.01 mg/kg for CBN 6. The LOAEL for CBN 7 was 0.1 mg/kg and also was identified from suppression in IgM responses. These results are of concern given the frequent off-road vehicle traffic and high visitor rates at the NDRA, estimated M 300,000 each year.
英文关键词	Geogenic dust Heavy metals Particulate matter Immunotoxicity Neurotoxicity
类型	Article
语种	英语
开放获取类型	Green Published, Other Gold
收录类别	ESCI
WOS记录号	WOS:000452653400035
WOS关键词	ROAD VEHICULAR ACTIVITY ; DUNES RECREATION AREA ; NELLIS DUNES ; LAS-VEGAS ; SUBACUTE EXPOSURE ; GEOGENIC DUST ; WIND EROSION ; PM10 ; NEUROTOXICITY ; EXPRESSION
WOS类目	Toxicology
WOS研究方向	Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333128
作者单位	[Keil, Deborah E.; Murphy, Lacey; Leetham-Spencer, Mallory] Montana State Univ, Dept Microbiol & Immunol, POB 173520, Bozeman, MT 59717 USA; [Buck, Brenda; Teng, Yuanxin; Pollard, James] Univ Nevada, Dept Geosci, 4505 S Maryland Pkwy, Las Vegas, NV 89154 USA; [Goossens, Dirk] Katholieke Univ Leuven, Dept Earth & Environm Sci, Celestijnenlaan 200E, B-3001 Leuven, Belgium; [McLaurin, Brett] Bloomsburg Univ Penn, Dept Environm Geog & Geol Sci, Bloomsburg, PA 17815 USA; [Gerads, Russell] Brooks Appl Labs, 18804 North Creek Pkwy, Bothell, WA 98011 USA; [DeWitt, Jamie C.] East Carolina Univ, Dept Pharmacol & Toxicol, 600 Moye Blvd, Greenville, NC 27834 USA
推荐引用方式 GB/T 7714	Keil, Deborah E.,Buck, Brenda,Goossens, Dirk,et al. Nevada desert dust with heavy metals suppresses IgM antibody production[J],2018,5:258-269.
APA	Keil, Deborah E..,Buck, Brenda.,Goossens, Dirk.,McLaurin, Brett.,Murphy, Lacey.,...&DeWitt, Jamie C..(2018).Nevada desert dust with heavy metals suppresses IgM antibody production.TOXICOLOGY REPORTS,5,258-269.
MLA	Keil, Deborah E.,et al."Nevada desert dust with heavy metals suppresses IgM antibody production".TOXICOLOGY REPORTS 5(2018):258-269.