干旱区生态环境知识资源中心(Arid): Simultaneous rapid determination of 12 anti-allergic chemical drugs in Chinese traditional patent medicine and health food by supercritical fluid chromatography tandem mass spectrometry with solid phase extraction

Arid

DOI	10.3724/SP.J.1123.2018.04006
	Simultaneous rapid determination of 12 anti-allergic chemical drugs in Chinese traditional patent medicine and health food by supercritical fluid chromatography tandem mass spectrometry with solid phase extraction
	Yang Zhi; Peng Yan; Jin Mengna; Lin Liqin
通讯作者	Yang, Z
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2018
卷号	36 期号:9 页码:889-894
英文摘要	An analytical method was developed for simultaneous rapid determination of 12 anti-allergic chemical drugs in Chinese traditional patent medicine and health food by supercritical fluid chromatography tandem mass spectrometry with solid phase extraction (SPE-SFC-MS/MS). Samples were extracted with methanol by sonification and then purified by Oasis mixed-model cation exchange SPE. The extracts were separated on a Waters Trefoil CEL1 (150 mmx 3. 0 mm, 2.5 mu m) column with a mobile phase consisting of carbon dioxide-methanol containing 0. 1% (v/v) ammonia water in a gradient elution mode, at a flow rate of 1.2 mL/min. The column temperature was 45 degrees C and the back pressure was 12. 4x10(6) Pa. The whole analysis was completed in 10 min. The 12 anti-allergic chemical drugs were detected by an electrospray ion source in positive or negative modes with a multiple reaction monitoring (MRM) mode. The calibration curves of the 12 anti-allergic chemical drugs showed good linearities in the range of 5 -250 mu g/L with the correlation coefficients (r) >= 0. 998. The limits of detection (LODs ) were 0. 141-0.262 mu g/L , and the limits of quantification ( LOQs ) were 0.703 - 1. 308 mu g/L. The recoveries of the 12 anti-allergic chemical drugs at spiked levels of 10, 20 and 100 mu g/L were in the range of 76. 1%-112. 5% , and the relative standard deviations (RSDs) were 1. 1%-8. 3% (n =6). The method is simple , sensitive and reliable. It has been successfully used for the detection of illegally added anti-allergic chemical drugs in Chinese traditional patent medicine and health food.
英文关键词	supercritical fluid chromatography (SFC) mass spectrometry (MS) solid phase extraction (SPE) anti-allergic chemical drug Chinese traditional patent medicine health food
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000452620500008
WOS关键词	CETIRIZINE
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333127
作者单位	[Yang Zhi; Peng Yan; Jin Mengna; Lin Liqin] Hangzhou Inst Food & Drug Control, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Yang Zhi,Peng Yan,Jin Mengna,et al. Simultaneous rapid determination of 12 anti-allergic chemical drugs in Chinese traditional patent medicine and health food by supercritical fluid chromatography tandem mass spectrometry with solid phase extraction[J],2018,36(9):889-894.
APA	Yang Zhi,Peng Yan,Jin Mengna,&Lin Liqin.(2018).Simultaneous rapid determination of 12 anti-allergic chemical drugs in Chinese traditional patent medicine and health food by supercritical fluid chromatography tandem mass spectrometry with solid phase extraction.CHINESE JOURNAL OF CHROMATOGRAPHY,36(9),889-894.
MLA	Yang Zhi,et al."Simultaneous rapid determination of 12 anti-allergic chemical drugs in Chinese traditional patent medicine and health food by supercritical fluid chromatography tandem mass spectrometry with solid phase extraction".CHINESE JOURNAL OF CHROMATOGRAPHY 36.9(2018):889-894.