干旱区生态环境知识资源中心(Arid): Simultaneous determination of 15 water-holding functional drugs in animal tissues using ultra performance liquid chromatography-tandem mass spectrometry

Arid

DOI	10.3724/SP.J.1123.2017.11003
	Simultaneous determination of 15 water-holding functional drugs in animal tissues using ultra performance liquid chromatography-tandem mass spectrometry
	Liu Hongbin; Yao Ximei; Tian Yaping; Zhang Lu; Cai Yinghua; Jiang Yanbin; Li Ying
通讯作者	Li, Y
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2018
卷号	36 期号:4 页码:400-407
英文摘要	A method based on ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the determination of 15 water-holding functional drugs in animal tissues. The analytes were extracted with acetonitrile containing 1.0% ( v/v) methanol, purified by Oasis PRIME HLB SPE column, and analyzed by Acquity UPLC BEH C18 column (50 mmx2.1 mm, 1.7 mu m) using methanol and 0. 1% (v/v) formic acid aqueous solution as the mobile phases. The analytes were detected using an electrospray ionization ( ESI) source under the MRM mode. The calibration curves of the analytes were linear in the range of 1. 0-50. 0 mu g/kg (r >= 0. 994 9) , and the limits of quantification were all less than 1.0 mu g/kg in animal tissues. The recoveries of the 15 water-holding functional drugs ranged from 60. 0%111. 0%in animal tissue samples, with the intra and inter RSDs of 0. 56% -11. 5% and 2. 31%14. 8%, respectively. The method can meet the requirements for the determination of the drug residues in animal tissues. It provides a new idea to identify potential hazards in animal-derived foods and to monitor illegal addition.
英文关键词	ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) residues water-holding functional drugs animal tissues
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000452608800013
WOS关键词	RESIDUES
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/333125
作者单位	[Liu Hongbin; Tian Yaping; Zhang Lu; Cai Yinghua; Jiang Yanbin; Li Ying] China Anim Dis Control Ctr, Beijing 102609, Peoples R China; [Yao Ximei] China Assoc Standardizat, Beijing 100048, Peoples R China
推荐引用方式 GB/T 7714	Liu Hongbin,Yao Ximei,Tian Yaping,et al. Simultaneous determination of 15 water-holding functional drugs in animal tissues using ultra performance liquid chromatography-tandem mass spectrometry[J],2018,36(4):400-407.
APA	Liu Hongbin.,Yao Ximei.,Tian Yaping.,Zhang Lu.,Cai Yinghua.,...&Li Ying.(2018).Simultaneous determination of 15 water-holding functional drugs in animal tissues using ultra performance liquid chromatography-tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,36(4),400-407.
MLA	Liu Hongbin,et al."Simultaneous determination of 15 water-holding functional drugs in animal tissues using ultra performance liquid chromatography-tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 36.4(2018):400-407.