干旱区生态环境知识资源中心(Arid): Nigragillin, Nigerazine B and Five Naphtho-gamma-pyrones from Aspergillus japonicus Isolated from Hot Desert Soil

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DOI	10.2174/2210315507666170306165326
	Nigragillin, Nigerazine B and Five Naphtho-gamma-pyrones from Aspergillus japonicus Isolated from Hot Desert Soil
	Magdy, Wesam; Abdel-Motaal, Fatma F.; El-Zayat, Soad A.; El-Sayed, Magdi A.; Helaly, Soleiman E.
通讯作者	El-Sayed, MA
来源期刊	NATURAL PRODUCTS JOURNAL
ISSN	2210-3155
EISSN	2210-3163
出版年	2017
卷号	7 期号:3 页码:216-223
英文摘要	Background: Microorganisms are highly diverse sources of bioactive natural products. A valuable set of fungi has been encountered in the hot Egyptian desert soils. The aims of this paper were to isolate soil thermophilic fungi and detect their bioactive metabolites. Methods: Direct incorporation method of soil into PDA medium is used for fungal isolation. The metabolic extracts of the isolated fungi were assayed against four bacterial species, Escherichia coli, Staphylococcus aureus, Neisseria lactamica and Bacillus subtilis. Phytochemical methods were used to isolate active compounds from Aspergillus japonicas. Their structures were determined by the interpretation of the NMR data and high resolution mass spectrometry (HRESIMS). Results: The Ethyl acetate extract of Aspergillus japonicus inhibited the growth of Bacillus subtilis, Escherichia coli, Neisseria lactamica and Staphylococcus aureus. Metabolomic investigation of A. japonicus extra-cellular secretion resulted in the isolation of nigragillin (1); and nigerazine B (2); along with five naphtho-gamma-pyrones, flavoasperone (3); rubrofusarin B (4); dianhydroaurasperone C (5); fonsecinone A (6); and aurasperone A (7). The antimicrobial activity of the isolated compounds is also described in this paper. Conclusion: This is the first report on those secondary metabolites from A. japonicus as well as the first full NMR assignments of nigerazine B (2). A. japonicas Compounds 1, 3, 4 and 7 exhibited antibacterial activities against B. subtilis, E. coli, N. lactamica, and S. aureus. Aurasperone A (7), and flavasperone (3) were the most active compounds against the tested Gram positive and Gram negative bacteria.
英文关键词	Soil fungi Aspergillus japonicus piperazine naphtho-gamma-pyrone natural products secondary metabolites antibacterial
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000410890500007
WOS关键词	FUNGI ; METABOLITES ; BIOTRANSFORMATION ; FERMENTATION ; ANTIFUNGAL
WOS类目	Chemistry, Medicinal
WOS研究方向	Pharmacology & Pharmacy
Scopus学科分类	Aswan Univ, Fac Sci, Dept Chem, Aswan 81528, Egypt.
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/332251
作者单位	[Magdy, Wesam; Abdel-Motaal, Fatma F.; El-Zayat, Soad A.; El-Sayed, Magdi A.] Aswan Univ, Dept Bot, Fac Sci, Aswan 81528, Egypt; [Helaly, Soleiman E.] Aswan Univ, Fac Sci, Dept Chem, Aswan 81528, Egypt; [Helaly, Soleiman E.] Helmholtz Ctr Infect Res, Dept Microbial Drugs, Inhoffenstr 7, D-38124 Braunschweig, Germany
推荐引用方式 GB/T 7714	Magdy, Wesam,Abdel-Motaal, Fatma F.,El-Zayat, Soad A.,et al. Nigragillin, Nigerazine B and Five Naphtho-gamma-pyrones from Aspergillus japonicus Isolated from Hot Desert Soil[J],2017,7(3):216-223.
APA	Magdy, Wesam,Abdel-Motaal, Fatma F.,El-Zayat, Soad A.,El-Sayed, Magdi A.,&Helaly, Soleiman E..(2017).Nigragillin, Nigerazine B and Five Naphtho-gamma-pyrones from Aspergillus japonicus Isolated from Hot Desert Soil.NATURAL PRODUCTS JOURNAL,7(3),216-223.
MLA	Magdy, Wesam,et al."Nigragillin, Nigerazine B and Five Naphtho-gamma-pyrones from Aspergillus japonicus Isolated from Hot Desert Soil".NATURAL PRODUCTS JOURNAL 7.3(2017):216-223.