中文版 | English
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DOI10.3390/jof2040034
The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas
Kirkland, Theo N.
通讯作者Kirkland, TN
来源期刊JOURNAL OF FUNGI
EISSN2309-608X
出版年2016
卷号2期号:4
英文摘要Coccidioidomycosis (Valley Fever) is a disease caused by inhalation of Coccidioides spp. This neglected disease has substantial public health impact despite its geographic restriction to desert areas of the southwestern U.S., Mexico, Central and South America. The incidence of this infection in California and Arizona has been increasing over the past fifteen years. Several large cities are within the endemic region in the U.S. Coccidioidomycosis accounts for 25,000 hospital admissions per year in California. While most cases of coccidioidomycosis resolve spontaneously, up to 40% are severe enough to require anti-fungal treatment, and a significant number disseminate beyond the lungs. Disseminated infection involving the meninges is fatal without appropriate treatment. Infection with Coccidioides spp. is protective against a second infection, so vaccination seems biologically plausible. This review of efforts to develop a vaccine against coccidioidomycosis focuses on vaccine approaches and the difficulties in identifying protein antigen/adjuvant combinations that protect in experimental mouse models. Although the quest for a vaccine is still in the early stage, scientific efforts for vaccine development may pave the way for future success.
英文关键词Coccidioides immitis Coccidioides posadasii coccidioidomycosis vaccine immunology fungi T-cell mediated immunity
类型Review
语种英语
开放获取类型DOAJ Gold, Green Published
收录类别ESCI
WOS记录号WOS:000453176000009
WOS关键词RECOMBINANT PROTEIN ; IMMITIS ; POSADASII ; MICE ; PROTECTION ; IMMUNITY ; ANTIGEN ; IMMUNIZATION ; RESISTANCE ; INFECTION
WOS类目Microbiology ; Mycology
WOS研究方向Microbiology ; Mycology
Scopus学科分类Univ Calif San Diego, Sch Med, Dept Med, San Diego, CA 92161 USA.
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/332038
作者单位[Kirkland, Theo N.] Univ Calif San Diego, Sch Med, Dept Pathol, San Diego, CA 92161 USA; [Kirkland, Theo N.] Univ Calif San Diego, Sch Med, Dept Med, San Diego, CA 92161 USA
推荐引用方式
GB/T 7714		 Kirkland, Theo N.. The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas[J],2016,2(4).
APA Kirkland, Theo N..(2016).The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas.JOURNAL OF FUNGI,2(4).
MLA Kirkland, Theo N.."The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas".JOURNAL OF FUNGI 2.4(2016).
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