干旱区生态环境知识资源中心(Arid): Magnetic graphene based dispersive micro-solid-phase extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry for the analysis of nine non-steroidal anti-inflammatory drugs in livestock and poultry meat

Arid

DOI	10.3724/SP.J.1123.2016.04039
	Magnetic graphene based dispersive micro-solid-phase extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry for the analysis of nine non-steroidal anti-inflammatory drugs in livestock and poultry meat
	Dong Chanchan; Hu Yanyun; Lu Yaning; Song Wei; Han Fang; Zheng Ping; Deng Ning
通讯作者	Hu, YY
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2016
卷号	34 期号:9 页码:850-859
英文摘要	A novel analytical method was developed for the determination of nine non. steroidal anti-inflammatory drugs (NSAIDs) in meat samples by magnetic graphene nanocomposite (Fe3O4-G) based on dispersive micro-solid-phase extraction (mu-SPE) coupled with liquid chromatography. mass spectrometry detection. Samples were homogenized and extracted with acidified acetonitrile. After defatting with the high speed frozen centrifugation, the sample solutions were defatted with n-hexane followed by mu-SPE. Some important parameters influencing the extraction efficiency including the extraction time, the pH value of sample solution and the elution conditions were optimized. The limits of detection (LODs, S/N = 3) of the nine NSAIDs ranged from 0.2 to 8.2 mu g/kg, and the limits of quantification (LOQs, S/N = 10) ranged from 0.5 to 25.4 mu g/kg. The average recoveries were 83.3%-104.5% with the relative standard deviations between 1.2% and 6.8% obtained from samples spiked at LOQ, 2LOQ and 10LOQ levels. Compared with Sep-Pak Vac NH2 and Oasis HLB cartridges, Fe3O4-G has excellent purification effect, high loading amounts and good reusability. The results demonstrated that the method provide a novel pretreatment technique for the determination of NSAID residues in meat samples.
英文关键词	dispersive micro-solid-phase extraction liquid chromatography-quadrupole mass spectrometry (LC-MS/MS) magnetic graphene nanocomposite non-steroidal anti-inflammatory drugs livestock and poultry meat
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000411229600004
WOS关键词	ENVIRONMENTAL WATER SAMPLES ; GAS-CHROMATOGRAPHY ; RESIDUES ; NANOPARTICLES ; ADSORBENT ; MUSCLE ; SERUM
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
Scopus学科分类	Anhui Med Univ, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China.
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/331931
作者单位	[Dong Chanchan; Deng Ning] Hefei Univ Technol, Sch Chem & Chem Technol, Hefei 230009, Anhui, Peoples R China; [Hu Yanyun; Lu Yaning; Song Wei; Han Fang; Zheng Ping] Anhui Entry Exit Inspect & Quarantine Bur, Hefei 230022, Anhui, Peoples R China; [Lu Yaning; Song Wei; Han Fang; Zheng Ping] Anhui Prov Key Lab Anal & Detect Food Safety, Hefei 230022, Anhui, Peoples R China; [Hu Yanyun] Anhui Med Univ, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Dong Chanchan,Hu Yanyun,Lu Yaning,et al. Magnetic graphene based dispersive micro-solid-phase extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry for the analysis of nine non-steroidal anti-inflammatory drugs in livestock and poultry meat[J],2016,34(9):850-859.
APA	Dong Chanchan.,Hu Yanyun.,Lu Yaning.,Song Wei.,Han Fang.,...&Deng Ning.(2016).Magnetic graphene based dispersive micro-solid-phase extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry for the analysis of nine non-steroidal anti-inflammatory drugs in livestock and poultry meat.CHINESE JOURNAL OF CHROMATOGRAPHY,34(9),850-859.
MLA	Dong Chanchan,et al."Magnetic graphene based dispersive micro-solid-phase extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry for the analysis of nine non-steroidal anti-inflammatory drugs in livestock and poultry meat".CHINESE JOURNAL OF CHROMATOGRAPHY 34.9(2016):850-859.