干旱区生态环境知识资源中心(Arid): EVALUATION OF ANTI- HYPERGLYCAEMIC ACTIVITY OF MAYTENUS EMARGINATUS WILLD LEAVES EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN WISTAR RATS

Arid

DOI	10.13040/IJPSR.0975-8232.7(6).2625-31
	EVALUATION OF ANTI- HYPERGLYCAEMIC ACTIVITY OF MAYTENUS EMARGINATUS WILLD LEAVES EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN WISTAR RATS
	Bishnoi, Navita; Shrivastava, B.; Bairwa, Ranjan; Sah, Sushil Kumar
通讯作者	Bishnoi, N
来源期刊	INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
ISSN	0975-8232
出版年	2016
卷号	7 期号:6
英文摘要	Maytenus emarginatus Willd. Celeastraceae, popularly known as "Kankeri or kankero", is a Thorny staff evergreen tree that is rich in various chemical constituents that determine the medicinal potential of this species. Diabetes mellitus is a disease that is affecting major population of the world. This study aimed to evaluate the antihyperglycaemic activity of the hydroalcoholic extract of the leaves of Maytenus emarginatus plant which is widely found in dry and arid regions of India mainly in Rajasthan. The hydroalcholic extract of the leaves of M. emarginata (250 and 500 mg/kg/day) were administered orally to streptozotocin-induced diabetic rats (n = 6/group) for 21 days. Changes in body weight, food and water intake, biochemical markers, fasting glucose levels and oral glucose tolerance test were evaluated. The results showed that the M. emarginatus dried extract (250 and 500 mg/kg) reduced significantly the level of blood glucose comparable to glibenclamide (10mg/kg) throughout the evaluation period and improved metabolic status of the animals and ameliorate the oral tolerance glucose test. Thus, we conclude that the extract of the leaves of M. emarginatus has antihyperglycemic activity.
英文关键词	Antihyperglycemic Streptozotocin Maytenus emarginatus
类型	Article
语种	英语
开放获取类型	Other Gold
收录类别	ESCI
WOS记录号	WOS:000391183200045
WOS关键词	METABOLISM
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/331722
作者单位	[Bishnoi, Navita; Shrivastava, B.; Bairwa, Ranjan; Sah, Sushil Kumar] Jaipur Natl Univ, Sch Pharmaceut Sci, Jaipur 302017, Rajasthan, India
推荐引用方式 GB/T 7714	Bishnoi, Navita,Shrivastava, B.,Bairwa, Ranjan,et al. EVALUATION OF ANTI- HYPERGLYCAEMIC ACTIVITY OF MAYTENUS EMARGINATUS WILLD LEAVES EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN WISTAR RATS[J],2016,7(6).
APA	Bishnoi, Navita,Shrivastava, B.,Bairwa, Ranjan,&Sah, Sushil Kumar.(2016).EVALUATION OF ANTI- HYPERGLYCAEMIC ACTIVITY OF MAYTENUS EMARGINATUS WILLD LEAVES EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN WISTAR RATS.INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH,7(6).
MLA	Bishnoi, Navita,et al."EVALUATION OF ANTI- HYPERGLYCAEMIC ACTIVITY OF MAYTENUS EMARGINATUS WILLD LEAVES EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN WISTAR RATS".INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 7.6(2016).