干旱区生态环境知识资源中心(Arid): ANTIDIABETIC, ANTIOXIDANT AND ANTI-HYPERLIPIDAEMIC ACTIVITY OF CUCUMIS CALLOSUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Arid

DOI	10.13040/IJPSR.0975-8232.7(5).1978-84
	ANTIDIABETIC, ANTIOXIDANT AND ANTI-HYPERLIPIDAEMIC ACTIVITY OF CUCUMIS CALLOSUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
	Panda, Sivaprasad; Chakraborty, Mainak; Majumder, Poulami; Mazumder, Suchandra; Das, Sudipta; Haldar, Pallab Kanti
通讯作者	Haldar, PK
来源期刊	INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
ISSN	0975-8232
出版年	2016
卷号	7 期号:5 页码:1978-1984
英文摘要	Cucumis callosus (Rottl.) Cogn. (Cucurbitaceae) is a highly branched very common prostate, perennial herb, distributed throughout India in the arid zones. Objective: To evaluate the antihyperglycemic potential of C. callosus fruit in experimental animal model. Materials and methods: Hyperglycemia was induced in rats by single intraperitoneal injection of STZ (55 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with MECC at the doses of 200 and 400 mg/kg body weight (p.o.) daily for 15 days. Glibenclamide (0.5 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every 5th day during the 15 days of treatment. Serum biochemical parameters including lipid content were estimated. Results and discussion: MECC at the doses of 200 and 400 mg/kg significantly (P < 0.01) and dose dependently reduced blood glucose levels towards normal as compared to that of STZ control group; the higher dose (400 mg/kg) being the most potent showing complete normalization of blood glucose levels. Serum biochemical parameters including lipid profile were significantly (p < 0.01) restored toward normal levels in MECC-treated rats as compared to STZ control group. Conclusion: The present study concludes that Cucumis callosus fruit demonstrated promising hypoglycemic action in STZ-induced diabetic rats substantiating its ethnomedicinal use.
英文关键词	Antidiabetic glibenclamide streptozotocin Cucumis callosus
类型	Article
语种	英语
开放获取类型	Other Gold
收录类别	ESCI
WOS记录号	WOS:000390405100018
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/331696
作者单位	[Panda, Sivaprasad] Coll Pharmaceut Sci, Puri Konark Marine Dr Rd,Puri 2, Odisha 752002, India; [Chakraborty, Mainak; Majumder, Poulami; Mazumder, Suchandra; Haldar, Pallab Kanti] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, W Bengal, India; [Das, Sudipta] Netaji Subhas Chandra Bose Inst Pharm, Nadia 741222, W Bengal, India
推荐引用方式 GB/T 7714	Panda, Sivaprasad,Chakraborty, Mainak,Majumder, Poulami,et al. ANTIDIABETIC, ANTIOXIDANT AND ANTI-HYPERLIPIDAEMIC ACTIVITY OF CUCUMIS CALLOSUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS[J],2016,7(5):1978-1984.
APA	Panda, Sivaprasad,Chakraborty, Mainak,Majumder, Poulami,Mazumder, Suchandra,Das, Sudipta,&Haldar, Pallab Kanti.(2016).ANTIDIABETIC, ANTIOXIDANT AND ANTI-HYPERLIPIDAEMIC ACTIVITY OF CUCUMIS CALLOSUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH,7(5),1978-1984.
MLA	Panda, Sivaprasad,et al."ANTIDIABETIC, ANTIOXIDANT AND ANTI-HYPERLIPIDAEMIC ACTIVITY OF CUCUMIS CALLOSUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS".INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 7.5(2016):1978-1984.