干旱区生态环境知识资源中心(Arid): Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis

Arid

DOI	10.1016/j.gdata.2014.11.016
	Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis
	John, Sumi Elsa; Thareja, Gaurav; Hebbar, Prashantha; Behbehani, Kazem; Thanaraj, Thangavel Alphonse; Alsmadi, Osama
通讯作者	Thanaraj, TA
来源期刊	GENOMICS DATA
ISSN	2213-5960
出版年	2015
卷号	3 页码:116-127
英文摘要	Kuwaiti native population comprises three distinct genetic subgroups of Persian, "city-dwelling" Saudi Arabian tribe, and nomadic "tent-dwelling" Bedouin ancestry. Bedouin subgroup is characterized by presence of 17% African ancestry; it owes it origin to nomadic tribes of the deserts of Arabian Peninsula and North Africa. By sequencing whole genome of a Kuwaiti male from this subgroup at 41X coverage, we report 3,752,878 SNPs, 411,839 indels, and 8451 structural variations. Neighbor-joining tree, based on shared variant positions carrying disease-risk alleles between the Bedouin and other continental genomes, places Bedouin genome at the nexus of African, Asian, and European genomes in concordance with geographical location of Kuwait and Peninsula. In congruence with participant's medical history for morbid obesity and bronchial asthma, risk alleles are seen at deleterious SNPs associated with obesity and asthma. Many of the observed deleterious 'novel' variants lie in genes associated with autosomal recessive disorders characteristic of the region. (c) 2015 The Authors. Published by Elsevier Inc.
英文关键词	Whole genome sequence Arabian Peninsula Nomadic Bedouin ancestry Kuwaiti population Intergenome distances "Tent-dwelling" Bedouins
类型	Article
语种	英语
开放获取类型	DOAJ Gold, Green Published
收录类别	ESCI
WOS记录号	WOS:000362674200028
WOS关键词	MITOCHONDRIAL-DNA ; WIDE ASSOCIATION ; STRUCTURAL VARIATION ; GENETIC-VARIATION ; VARIANTS ; MUTATIONS ; DIVERSITY ; SNP ; FRAMEWORK ; ALGORITHM
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/331146
作者单位	[John, Sumi Elsa; Thareja, Gaurav; Hebbar, Prashantha; Behbehani, Kazem; Thanaraj, Thangavel Alphonse; Alsmadi, Osama] Dasman Diabet Inst, POB 1180, Dasman 15462, Kuwait
推荐引用方式 GB/T 7714	John, Sumi Elsa,Thareja, Gaurav,Hebbar, Prashantha,et al. Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis[J],2015,3:116-127.
APA	John, Sumi Elsa,Thareja, Gaurav,Hebbar, Prashantha,Behbehani, Kazem,Thanaraj, Thangavel Alphonse,&Alsmadi, Osama.(2015).Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis.GENOMICS DATA,3,116-127.
MLA	John, Sumi Elsa,et al."Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis".GENOMICS DATA 3(2015):116-127.