干旱区生态环境知识资源中心(Arid): Immunohistochemical (IHC) Analysis of Non-Hodgkin's Lymphoma (NHL) Spectrum According to WHO/REAL Classification: A Single Centre Experience from Punjab, India

Arid

DOI	10.7860/JCDR/2014/8173.3988
	Immunohistochemical (IHC) Analysis of Non-Hodgkin's Lymphoma (NHL) Spectrum According to WHO/REAL Classification: A Single Centre Experience from Punjab, India
	Sharma, Manisha; Mannan, Rahul; Madhukar, Mohit; Navani, Sanjay; Manjari, Mridu; Bhasin, Tejinder Singh; Gill, Karamjit Singh
通讯作者	Mannan, R
来源期刊	JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
ISSN	2249-782X
EISSN	0973-709X
出版年	2014
卷号	8 期号:1 页码:46-49
英文摘要	Introduction: The distribution of the major subtypes of non-Hodgkin's lymphoma (NHL) differs across geographic regions. This study, from the north Indian state of Punjab, has incorporated immunophenotypic findings while investigating the distribution of NHL subtypes based on World Health Organization (WHO)/Revised European-American Classification of Lymphoid Neoplasms (REAL) system of classification. Patients and methods: Over all seventy seven cases of lymphoma over a period of one year (between April 2012 and April 2013) were diagnosed in the Department of Pathology, Sri Guru Ram Des Institute of Medical Sciences and Research, Amritsar (Punjab). Of these 30 cases (39%) were of Hodgkin's Lymphoma (HL) and 47 cases (61%) were of Non Hodgkins lymphoma NHL. Of the total of cases of lympho-proliferative disorders, the diagnosis of NHL was done by light microscopy alone. All the cases diagnosed provisionally as NHL were taken up for inrinnunophenotyping with Immunohistochemical (INC) studies. There was 100 % concordance between the light microscopy and IHC studies. The individual NHL cases were classified according to the WHO/ REAL classification according to the positive or relevant negative immonophenotypic expression and tabulated to ascertain the morphological spectrum of NHL in this part of the country. Results: B-cell lymphomas formed 89.3%, whereas T-cell lymphomas formed 107% of the NHLs. Diffuse Large B-Cell Lymphoma (DLBCL) was the most common subtype (46.8% of all NHLs), B-cell small lymphocytic lymphoma, Mantle-Cell Lymphoma (MCL), marginal zone B-cell lymphomas (including MALT lymphomas). Diffuse, mixed small cleaved cell and large cell type and Follicular centre-cell lymphomas amounted to 17%, 12.8%, 2.1%, 2.1% and 4.3%. respectively. Among the T-cell lymphomas, T-cell lymphoblastic lymphoma, anaplastic large cell lymphomas of T/null-cell type, and Angioimmunoblastic T-cell lymphoma (AITL) accounted for 6.4%, 2.1%, and 2.1% of all NHL cases, respectively. Conclusions: The distribution of NHL subtypes in India shows disparity with those from the rest of the world. Follicular Lymphoma (FL) and MCL are less common in India compared to Europe and the USA. Peripheral T-cell lymphomas and T/NK-cell lymphomas of nasal and nasal types, which are common in many other Asian countries, are also less prevalent. T-cell lymphoblastic lymphoma arid anaplastic large T/null cell lymphoma are more prevalent in India.
英文关键词	Non Hodgkins lymphoma WHO/REAL classification lmmunophenotyping B-cell lymphomas T-cell lymphomas
类型	Article
语种	英语
开放获取类型	DOAJ Gold, Green Published
收录类别	ESCI
WOS记录号	WOS:000422327700014
WOS关键词	INCIDENCE PATTERNS ; CELL LYMPHOMA ; DIAGNOSIS ; SUBTYPE ; REAL
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330919
作者单位	[Sharma, Manisha; Mannan, Rahul; Madhukar, Mohit; Navani, Sanjay; Manjari, Mridu; Bhasin, Tejinder Singh; Gill, Karamjit Singh] Sri Guru Ram Das Inst Med Sci & Res, Dept Pathol, Amritsar, Punjab, India
推荐引用方式 GB/T 7714	Sharma, Manisha,Mannan, Rahul,Madhukar, Mohit,et al. Immunohistochemical (IHC) Analysis of Non-Hodgkin's Lymphoma (NHL) Spectrum According to WHO/REAL Classification: A Single Centre Experience from Punjab, India[J],2014,8(1):46-49.
APA	Sharma, Manisha.,Mannan, Rahul.,Madhukar, Mohit.,Navani, Sanjay.,Manjari, Mridu.,...&Gill, Karamjit Singh.(2014).Immunohistochemical (IHC) Analysis of Non-Hodgkin's Lymphoma (NHL) Spectrum According to WHO/REAL Classification: A Single Centre Experience from Punjab, India.JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH,8(1),46-49.
MLA	Sharma, Manisha,et al."Immunohistochemical (IHC) Analysis of Non-Hodgkin's Lymphoma (NHL) Spectrum According to WHO/REAL Classification: A Single Centre Experience from Punjab, India".JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 8.1(2014):46-49.