干旱区生态环境知识资源中心(Arid): Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment

Arid

DOI	10.1586/17446651.2014.949241
	Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment
	Majnik, Amber; Gunn, Veronica; Fu, Qi; Lane, Robert H.
通讯作者	Lane, RH
来源期刊	EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
ISSN	1744-6651
EISSN	1744-8417
出版年	2014
卷号	9 期号:6 页码:605-614
英文摘要	Obesity and its consequences impact everyone. Obesity occurs because of an interaction between an obesogenic environment and genetics. In order to confront obesity, we must understand the contribution of each of these components. Environmental influences on obesity include our extrinsic environment, such as food deserts, as well as our intrinsic environment, like perinatal exposures. Epigenetics provides a biological mechanism to reveal the accumulation of extrinsic and intrinsic environmental exposures from fetal life to adulthood. Human and animal studies demonstrate changes in epigenetic modifications which are associated with an obesogenic environment. Furthermore, evidence exists in humans and animal models that suggest environmental epigenetics may serve as a biomarker or a target for intervention. To successfully target obesity, we must intervene on an environmental as well as genetic level. Combating food deserts for example will help to change the extrinsic environment, while targeting epigenetic modification remains a goal for changing our biology.
英文关键词	DNA methylation epigenetics food desert histone covalent modification life course model maternal obesity obesogenic environment
类型	Review
语种	英语
收录类别	ESCI
WOS记录号	WOS:000420064400007
WOS关键词	1959-1961 CHINESE FAMINE ; JUNK FOOD DIET ; DNA METHYLATION ; MATERNAL OBESITY ; DIFFERENTIAL METHYLATION ; PHYSICAL-ACTIVITY ; ADIPOSE-TISSUE ; WEIGHT ; EXPRESSION ; CHILDREN
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330877
作者单位	[Majnik, Amber; Fu, Qi] Med Coll Wisconsin, Milwaukee, WI 53226 USA; [Gunn, Veronica; Lane, Robert H.] Childrens Hosp Wisconsin, Childrens Corp Ctr, Suite 525,POB 1997, Milwaukee, WI 53201 USA
推荐引用方式 GB/T 7714	Majnik, Amber,Gunn, Veronica,Fu, Qi,et al. Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment[J],2014,9(6):605-614.
APA	Majnik, Amber,Gunn, Veronica,Fu, Qi,&Lane, Robert H..(2014).Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment.EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM,9(6),605-614.
MLA	Majnik, Amber,et al."Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment".EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM 9.6(2014):605-614.