Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.3724/SP.J.1123.2013.02028 |
Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry | |
Zhang Lin; Zhang Fucheng; Wang Zhaohong; Jiang Ye; Xu Meng; Li Hong | |
通讯作者 | Jiang, Y |
来源期刊 | CHINESE JOURNAL OF CHROMATOGRAPHY
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ISSN | 1000-8713 |
出版年 | 2013 |
卷号 | 31期号:9页码:898-902 |
英文摘要 | A rapid and sensitive method has been developed for the simultaneous determination of ephedrine and N-methylephedrine in urine samples by solid phase extraction-ultra performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (SPE-UPLC-ESI MS/MS). The samples were extracted with Oasis MCX solid phase extraction cartridges and measured in the modes of electrospray positive ionization (ESI +) and multiple reaction monitoring (MRM). Good linearities were observed in the range of 0.025 0 - 2.50 mu g/L with correlation coefficient over 0.999 0 for both analytes. The recoveries were above 80% with RSDs less than 5.0%. The limits of detection were 0.01 mu g/L. The method proves to be rapid and sensitive for the trace determination of ephedrine and N-methylephedrine in urine samples. |
英文关键词 | solid phase extraction (SPE) ultra performance liquid chromatography-electros-pray ionization tandem mass spectrometry (UPLC-ESI MS/MS) ephedrine N-methylephed-rine urine |
类型 | Article |
语种 | 中文 |
收录类别 | ESCI |
WOS记录号 | WOS:000434520100014 |
WOS类目 | Chemistry, Analytical |
WOS研究方向 | Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/330556 |
作者单位 | [Zhang Lin; Jiang Ye; Xu Meng] Hebei Med Univ, Sch Pharmacol, Shijiazhuang 050017, Hebei, Peoples R China; [Zhang Fucheng] Air Force Gen Hosp, Beijing 100142, Peoples R China; [Wang Zhaohong] Inst Forens Sci Supreme Peoples Procuratorate, Beijing 100040, Peoples R China; [Li Hong] Interpol Corps Yunnan Publ Secur Bur, Kunming 650000, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang Lin,Zhang Fucheng,Wang Zhaohong,et al. Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry[J],2013,31(9):898-902. |
APA | Zhang Lin,Zhang Fucheng,Wang Zhaohong,Jiang Ye,Xu Meng,&Li Hong.(2013).Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,31(9),898-902. |
MLA | Zhang Lin,et al."Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 31.9(2013):898-902. |
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