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DOI10.3724/SP.J.1123.2013.02028
Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry
Zhang Lin; Zhang Fucheng; Wang Zhaohong; Jiang Ye; Xu Meng; Li Hong
通讯作者Jiang, Y
来源期刊CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN1000-8713
出版年2013
卷号31期号:9页码:898-902
英文摘要A rapid and sensitive method has been developed for the simultaneous determination of ephedrine and N-methylephedrine in urine samples by solid phase extraction-ultra performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (SPE-UPLC-ESI MS/MS). The samples were extracted with Oasis MCX solid phase extraction cartridges and measured in the modes of electrospray positive ionization (ESI +) and multiple reaction monitoring (MRM). Good linearities were observed in the range of 0.025 0 - 2.50 mu g/L with correlation coefficient over 0.999 0 for both analytes. The recoveries were above 80% with RSDs less than 5.0%. The limits of detection were 0.01 mu g/L. The method proves to be rapid and sensitive for the trace determination of ephedrine and N-methylephedrine in urine samples.
英文关键词solid phase extraction (SPE) ultra performance liquid chromatography-electros-pray ionization tandem mass spectrometry (UPLC-ESI MS/MS) ephedrine N-methylephed-rine urine
类型Article
语种中文
收录类别ESCI
WOS记录号WOS:000434520100014
WOS类目Chemistry, Analytical
WOS研究方向Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/330556
作者单位[Zhang Lin; Jiang Ye; Xu Meng] Hebei Med Univ, Sch Pharmacol, Shijiazhuang 050017, Hebei, Peoples R China; [Zhang Fucheng] Air Force Gen Hosp, Beijing 100142, Peoples R China; [Wang Zhaohong] Inst Forens Sci Supreme Peoples Procuratorate, Beijing 100040, Peoples R China; [Li Hong] Interpol Corps Yunnan Publ Secur Bur, Kunming 650000, Yunnan, Peoples R China
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GB/T 7714
Zhang Lin,Zhang Fucheng,Wang Zhaohong,et al. Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry[J],2013,31(9):898-902.
APA Zhang Lin,Zhang Fucheng,Wang Zhaohong,Jiang Ye,Xu Meng,&Li Hong.(2013).Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,31(9),898-902.
MLA Zhang Lin,et al."Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 31.9(2013):898-902.
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