干旱区生态环境知识资源中心(Arid): A prospective randomized controlled trial to study the role of sulfasalazine in prevention of acute gastrointestinal toxicity associated with concurrent chemoradiation in carcinoma cervix

Arid

DOI	10.4103/2278-0513.113633
	A prospective randomized controlled trial to study the role of sulfasalazine in prevention of acute gastrointestinal toxicity associated with concurrent chemoradiation in carcinoma cervix
	Pal, Santanu; Adhikary, Shyam Sundar; Bhattacharya, Biswamit; Basu, Joydeep; Ghosh, Tanmoy; Patra, Niladri Behari
通讯作者	Pal, S
来源期刊	CLINICAL CANCER INVESTIGATION JOURNAL
ISSN	2278-0513
出版年	2013
卷号	2 期号:2 页码:118-121
英文摘要	Background: The primary aim of the study was to evaluate the effectiveness of sulfasalazine in reducing the incidence of acute radiation-induced enteritis in carcinoma cervix patients receiving pelvic external beam radiotherapy along with concurrent cisplatin-based chemotherapy. Materials and Methods: Between November 2011 and July 2012 a total of 98 patients of locoregionally advanced carcinoma of cervix (49 each in study and control arms) were enrolled in this study. Patients in both the arms were treated with whole pelvis external beam radiotherapy with total dose of 50 Gy in conventional fractionation. Along with this inj. cisplatin was given concurrently at the dose of 40 mg/m(2) of body surface area every week during radiation for 5 weeks. Concurrent chemoradiation was followed by brachytherapy after a gap of 2 weeks. Patients in the study arm also received tablet sulfasalazine 1,000 mg orally twice daily from the day of starting of radiotherapy to 1 week after completion of treatment. Weekly follow-up of all patients to assess acute toxicities was done using common toxicity criteria version 4.0 (CTC v4.0) toxicity scores. Data analysis was carried out by SPSS version 20.0 software. Results: Incidence of grade II or higher grade, lower gastrointestinal toxicity was 19.14% (09/47) in study arm and 41.66% (20/48) in control arm which was statistically significant (P = 0.017). Conclusion: The study shows that sulfasalazine can significantly reduce the acute radiation-induced diarrhea (ARID) in patients undergoing whole pelvis external beam radiotherapy for carcinoma cervix. The drug is safe, cheap, and readily available.
英文关键词	Chemoradiation diarrhoea sulfasalazine
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000219178700004
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330436
作者单位	[Pal, Santanu; Adhikary, Shyam Sundar; Bhattacharya, Biswamit; Basu, Joydeep; Ghosh, Tanmoy; Patra, Niladri Behari] Med Coll, Dept Radiotherapy, Kolkata, W Bengal, India
推荐引用方式 GB/T 7714	Pal, Santanu,Adhikary, Shyam Sundar,Bhattacharya, Biswamit,et al. A prospective randomized controlled trial to study the role of sulfasalazine in prevention of acute gastrointestinal toxicity associated with concurrent chemoradiation in carcinoma cervix[J],2013,2(2):118-121.
APA	Pal, Santanu,Adhikary, Shyam Sundar,Bhattacharya, Biswamit,Basu, Joydeep,Ghosh, Tanmoy,&Patra, Niladri Behari.(2013).A prospective randomized controlled trial to study the role of sulfasalazine in prevention of acute gastrointestinal toxicity associated with concurrent chemoradiation in carcinoma cervix.CLINICAL CANCER INVESTIGATION JOURNAL,2(2),118-121.
MLA	Pal, Santanu,et al."A prospective randomized controlled trial to study the role of sulfasalazine in prevention of acute gastrointestinal toxicity associated with concurrent chemoradiation in carcinoma cervix".CLINICAL CANCER INVESTIGATION JOURNAL 2.2(2013):118-121.