干旱区生态环境知识资源中心(Arid): Aqueous Extract of Balanites aegyptiaca Del Fruit Mesocarp Protects against CCl4

Arid

DOI	10.9734/BJPR/2013/4576
	Aqueous Extract of Balanites aegyptiaca Del Fruit Mesocarp Protects against CCl4 - Induced Liver Damage in Rats
	Mariam, Salihu; Onyenibe, Nwozo Sarah; Oyelola, Oloyede B.
通讯作者	Onyenibe, NS
来源期刊	BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH
ISSN	2231-2919
出版年	2013
卷号	3 期号:4 页码:917-928
英文摘要	Aim: Carry out preliminary phytochemical screening of Balanites aegyptiaca fruit mesocarp and to evaluate the ability of the aqueous extract to ameliorate carbon tetrachloride-induced hepatotoxicity in rats by determining liver enzymes, blood parameters and histopathology. Study Design: Sixty albino rats (Wistar rats) were randomly placed into four groups of fifteen animals: Group 1 (normal control), group 2 (Untreated CCl4 -intoxicated group) while groups 3 and 4 are test groups both administered CCl4 and 0.08 mgkg(-1) and 0.19 mgkg-1 body weight of concentrated fruit extract respectively orally daily. Administration of CCl4 was 3 times in a week for 4 weeks at a dose of 1.2 g/kg body weight and plant extract for 3 weeks. Results: Phytochemical screening indicated the presence of saponin, flavonoids, steroids, alkaloids and cardiac glycosides in the fruit mesocarp. Serum total proteins, albumin and conjugated bilirubin were elevated while the liver enzymes activities (alanine transaminase and alkaline phosphatase) were significantly reduced in the test groups 3 and 4 compared to the untreated rats (Group 2). Histological examinations of the rats' tissues showed reduced inflammation in the liver of the CCl4-damage rats treated with the extracts when compared to the control and the cell architecture on the 21st day of the animal treated with extract resembled that of the normal control. Conclusion: The mesocarp of desert dates ameliorates hepatotoxicity induced by CCl4 in rats and this study has further added credibility to the ethnobotanical use of the fruit.
英文关键词	Balanites aegyptiaca phytochemicals CCl4 liver enzymes histology
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000219000900031
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330431
作者单位	[Mariam, Salihu] Al Hikmah Univ, Coll Nat Sci, Biol Sci Dept, Biochem Unit, Ilorin, Kwara State, Nigeria; [Mariam, Salihu; Onyenibe, Nwozo Sarah] Univ Ibadan, Coll Med, Biochem Dept, Nutr Ind Biochem Unit,FBMS, Ibadan, Oyo State, Nigeria; [Oyelola, Oloyede B.] Univ Ilorin, Biochem Dept, Ilorin, Kwara State, Nigeria
推荐引用方式 GB/T 7714	Mariam, Salihu,Onyenibe, Nwozo Sarah,Oyelola, Oloyede B.. Aqueous Extract of Balanites aegyptiaca Del Fruit Mesocarp Protects against CCl4 - Induced Liver Damage in Rats[J],2013,3(4):917-928.
APA	Mariam, Salihu,Onyenibe, Nwozo Sarah,&Oyelola, Oloyede B..(2013).Aqueous Extract of Balanites aegyptiaca Del Fruit Mesocarp Protects against CCl4 - Induced Liver Damage in Rats.BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH,3(4),917-928.
MLA	Mariam, Salihu,et al."Aqueous Extract of Balanites aegyptiaca Del Fruit Mesocarp Protects against CCl4 - Induced Liver Damage in Rats".BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH 3.4(2013):917-928.