干旱区生态环境知识资源中心(Arid): Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review

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	Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review
	Shi, Lei; Ronfard, Vincent
通讯作者	Shi, L
来源期刊	INTERNATIONAL JOURNAL OF BURNS AND TRAUMA
ISSN	2160-2026
出版年	2013
卷号	3 期号:4 页码:173-179
英文摘要	Porcine small intestinal submucosa (SIS [Oasis ((R))]) is an acellular, biological extracellular matrix (ECM) that has been found to significantly improve the healing of difficult-to-heal or chronic wounds in humans. Like dermal ECM, SIS contains collagen, elastin, glycosaminoglycans, proteoglycans, and growth factors that play important roles in healing. Preclinical studies have shown that numerous cell types attach to SIS, proliferate and migrate into the matrix, and differentiate. In addition, SIS can reduce the activity of matrix metalloproteinases (MMPs)-endogenous proteolytic enzymes whose levels and activities are increased in chronic wounds. Compared to the original single-layer SIS, multi-layer SIS has stronger mechanical properties and is more slowly degraded in wounds. Together, these SIS products provide flexibility in the selection of biologically-active ECMs that may be useful for the repair of diverse wound types.
英文关键词	Small intestinal submucosa SIS extracellular matrix burn chronic wounds
类型	Review
语种	英语
收录类别	ESCI
WOS记录号	WOS:000218905200001
WOS关键词	DIABETIC FOOT ULCERS ; OASIS WOUND MATRIX ; EXTRACELLULAR-MATRIX ; LEG ULCERS ; IN-VITRO ; PROTEOGLYCANS ; FIBRONECTIN ; CYTOKINES ; ADHESION ; OUTCOMES
WOS类目	Emergency Medicine
WOS研究方向	Emergency Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330421
作者单位	[Shi, Lei; Ronfard, Vincent] Smith & Nephew, 3909 Hulen St, Ft Worth, TX 76107 USA
推荐引用方式 GB/T 7714	Shi, Lei,Ronfard, Vincent. Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review[J],2013,3(4):173-179.
APA	Shi, Lei,&Ronfard, Vincent.(2013).Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review.INTERNATIONAL JOURNAL OF BURNS AND TRAUMA,3(4),173-179.
MLA	Shi, Lei,et al."Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review".INTERNATIONAL JOURNAL OF BURNS AND TRAUMA 3.4(2013):173-179.