干旱区生态环境知识资源中心(Arid): Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb

Arid

DOI	10.1155/2013/802453
	Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb
	Sehgal, Inder; Winters, Wallace D.; Scott, Michael; David, Andrew; Gillis, Glenn; Stoufflet, Thaya; Nair, Anand; Kousoulas, Konstantine
通讯作者	Sehgal, I
来源期刊	JOURNAL OF TOXICOLOGY
ISSN	1687-8191
EISSN	1687-8205
出版年	2013
卷号	2013
英文摘要	Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/ subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. We found this DCW Laloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods. When fed to male and female F344 rats over 13 weeks, DCWLaloe led to no toxicity as assessed by behavior, stools, weight gain, feed consumption, organ weights, and hematologic or clinical chemistry profiles. These rats had intestinal mucosal morphologies-examined grossly and microscopically-that were similar to controls. Our studies show that oral administration of this DCWL aloe juice has a different toxicology profile than that of the untreated aloe juice at exposures up to 13 weeks.
类型	Article
语种	英语
开放获取类型	DOAJ Gold, Green Published
收录类别	ESCI
WOS记录号	WOS:000214720400020
WOS关键词	ANAEROBIC-BACTERIA ; GEL ; POLYSACCHARIDE ; GENOTOXICITY ; BARBALOIN ; TOXICITY ; EXTRACT ; SAFETY ; EMODIN
WOS类目	Toxicology
WOS研究方向	Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330302
作者单位	[Sehgal, Inder] LSU Sch Vet Med, Skip Bertman Dr, Baton Rouge, LA 70803 USA; [Sehgal, Inder; Nair, Anand] LSU Sch Vet Med, Comparat Biomed Sci Dept, Baton Rouge, LA 70803 USA; [Winters, Wallace D.; Scott, Michael] Technol & Toxicol ST&T Consultants, Sci, San Francisco, CA 94111 USA; [David, Andrew; Stoufflet, Thaya; Kousoulas, Konstantine] LSU Sch Vet Med, Div Biotechnol & Mol Med BIOMMED, Baton Rouge, LA 70803 USA; [Gillis, Glenn] Lily Desert, Denton, TX 76208 USA
推荐引用方式 GB/T 7714	Sehgal, Inder,Winters, Wallace D.,Scott, Michael,et al. Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb[J],2013,2013.
APA	Sehgal, Inder.,Winters, Wallace D..,Scott, Michael.,David, Andrew.,Gillis, Glenn.,...&Kousoulas, Konstantine.(2013).Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb.JOURNAL OF TOXICOLOGY,2013.
MLA	Sehgal, Inder,et al."Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb".JOURNAL OF TOXICOLOGY 2013(2013).