干旱区生态环境知识资源中心(Arid): Determination o the residues of 3-methyl-quinoxaline-2-carboxylic acid and quinoxaline-2-carboxylic acid in animal origin foods by high performance liquid chromatography-tandem mass spectrometry

Arid

DOI	10.3724/SP.J.1123.2012.02018
	Determination o the residues of 3-methyl-quinoxaline-2-carboxylic acid and quinoxaline-2-carboxylic acid in animal origin foods by high performance liquid chromatography-tandem mass spectrometry
	Zheng Ling; Wu Yujie; Li Yong; Li Lihua
通讯作者	Wu, YJ
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2012
卷号	30 期号:7 页码:660-664
英文摘要	A high performance liquid chromatography-tandem mass spectrometry HPLC-MS/MS method was developed for the simultaneous quantitative determination of 3-methyl-quinoxaline-2-carboxylic acid MQCA and quinoxaline-2-carboxylic acid QCA as the marker residues for carbadox CBX and olaquindox OLA respectively in the muscles and livers of porcine and chicken and in the muscles of fish and shrimp. The MQCA and QCA were deproteinated with 5% metaphosphoric acid in 10% methanol followed by liquid-liquid extraction. Further clean-up was performed by solid phase extraction SPE through mixed mode anionexchange columns Oasis MAX SPE . The separation of the compounds was carried on a Waters Xterra MS C18 column 150 mm x 2. 1 mm 5 mu m by a gradient elution using methanol and 0. 2% formic acid as mobile phases. The analytes were detected by tandem mass spectrometry in multiple reaction monitoring MRM mode with positive electrospray ionization. The MQCA and QCA were quantified by internal standard method. The linear ranges were 1. 0 - 20. 0 mu g/L and the correlation coefficients were not less than 0.999 6. The average recoveries and relative standard deviations ranged from 62.4% - 118% and 1.48% - 28. 1% respectively at the spiked levels of 0. 1 0.2 and 1.0 mu g/kg for the both markers. The limit of quantitation LOQ was 0. 1 mu g/kg. The method is sensitive accurate and suitable for the determination and confirmation of MQCA and QCA in animal origin foods.
英文关键词	high performance liquid chromatography-tandem mass spectrometry LC-MS/MS 3-methyl-quinoxalin-2-carboxylic acid MQCA quinoxaline-2-carboxylic acid QCA animal origin foods
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000435252300003
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330180
作者单位	[Zheng Ling; Wu Yujie; Li Yong; Li Lihua] Guangxi Entry Exit Inspect & Quarantine Bur, Nanning 530021, Peoples R China
推荐引用方式 GB/T 7714	Zheng Ling,Wu Yujie,Li Yong,et al. Determination o the residues of 3-methyl-quinoxaline-2-carboxylic acid and quinoxaline-2-carboxylic acid in animal origin foods by high performance liquid chromatography-tandem mass spectrometry[J],2012,30(7):660-664.
APA	Zheng Ling,Wu Yujie,Li Yong,&Li Lihua.(2012).Determination o the residues of 3-methyl-quinoxaline-2-carboxylic acid and quinoxaline-2-carboxylic acid in animal origin foods by high performance liquid chromatography-tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,30(7),660-664.
MLA	Zheng Ling,et al."Determination o the residues of 3-methyl-quinoxaline-2-carboxylic acid and quinoxaline-2-carboxylic acid in animal origin foods by high performance liquid chromatography-tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 30.7(2012):660-664.