干旱区生态环境知识资源中心(Arid): Simultaneous determination of 29 veterinary drugs in compound feeds by ultra performance liquid chromatography-electrospray ionization tandem quadrupole mass spectrometry

Arid

DOI	10.3724/SP.J.1123.2012.06019
	Simultaneous determination of 29 veterinary drugs in compound feeds by ultra performance liquid chromatography-electrospray ionization tandem quadrupole mass spectrometry
	Zhao Ying; Liu Yu; Jin Yan; Xu Yihong; Zhong Yu; Jiang Shi; Li Xiaodong; Zeng Fan; Zhou Jiannan
通讯作者	Zhao, Y
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2012
卷号	30 期号:9 页码:908-914
英文摘要	An ultra performance liquid chromatography with electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed for the simultaneous determination of 29 veterinary drugs of quinolones, sulfonamides, macrolides and nitrofurans in compound feeds. The sample was extracted with methanol-acetonitrile (1 : 1, v/v), and then cleaned up using solid phase extraction with an Oasis HLB column, detected by UPLC-ESI-MS/ MS. The UPLC separation was performed on a C18 column (100 mm x 2.1 mm, 1.7 microm) using a gradient elution with the mobile phases of methanol and 0. 1% (v/v) formic acid aqueous solution. The ESI-MS/MS detection was achieved in positive mode under multiple reaction monitoring (MRM) mode. The linear ranges were from 0.01 to 5.0 mg/L with the correlation coefficients above 0. 99 for all the 29 veterinary drugs. The average recoveries of the 29 veterinary drugs spiked in three feed matrixes (the compound premix feed, the complete formula feed and the concentrated feed) at four spiked levels were 61.2% - 94.3% with the relative standard deviations (RSDs) of 2.2% - 15.0%. The limits of detection were 0. 01 mg/kg or 0.05 mg/kg. The method is rapid, accurate, reproducible, sensitive and easy to apply, and suitable for the simultaneous determination of diverse veterinary drugs in compound feeds.
英文关键词	ultra performance liquid chromatography-electrospray ionization tandem quadrupole mass spectrometry (UPLC-ESI-MS/MS) veterinary drugs compound feeds
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000434511100009
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/330169
作者单位	[Zhao Ying; Liu Yu; Jin Yan; Xu Yihong; Zhong Yu; Jiang Shi; Li Xiaodong; Zeng Fan; Zhou Jiannan] Shenyang Entry Exist Inspect & Quarantine Bur, Technol Ctr, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Zhao Ying,Liu Yu,Jin Yan,et al. Simultaneous determination of 29 veterinary drugs in compound feeds by ultra performance liquid chromatography-electrospray ionization tandem quadrupole mass spectrometry[J],2012,30(9):908-914.
APA	Zhao Ying.,Liu Yu.,Jin Yan.,Xu Yihong.,Zhong Yu.,...&Zhou Jiannan.(2012).Simultaneous determination of 29 veterinary drugs in compound feeds by ultra performance liquid chromatography-electrospray ionization tandem quadrupole mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,30(9),908-914.
MLA	Zhao Ying,et al."Simultaneous determination of 29 veterinary drugs in compound feeds by ultra performance liquid chromatography-electrospray ionization tandem quadrupole mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 30.9(2012):908-914.