干旱区生态环境知识资源中心(Arid): Atherosclerosis and atherosensitivity in two southwest Algerian desert rodents, Psammomys obesus and Gerbillus gerbillus, and in Rattus norvegicus

Arid

DOI	10.2147/DMSO.S34875
	Atherosclerosis and atherosensitivity in two southwest Algerian desert rodents, Psammomys obesus and Gerbillus gerbillus, and in Rattus norvegicus
	El-Aoufi, Salima; Lazourgui, Mohamed-Amine; Griene, Lakhdar; Maouche, Boubekeur
通讯作者	El-Aoufi, S
来源期刊	DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
ISSN	1178-7007
出版年	2012
卷号	5 页码:337-345
英文摘要	Cardiovascular disease, including atherosclerosis, is the leading cause of death in patients with diabetes worldwide; thus, it is a major medical concern. The endothelium contributes to the control of many vascular functions, and clinical observations show that it is a primary target for diabetic syndrome. To get better insight into the mechanisms underlying atherosclerosis, we studied the interspecific differences in the arterial metabolisms of two, Psammomys obesus and Gerbillus gerbillus, as well as Rattus norvegicus (Wistar rat), well known for its atheroresistance. Twenty-two enzymatic activities and six macromolecular substances were histochemically compared in the two desert species and in Wistar aortas (abdominal and thoracic) and arteries (femoral and caudal) embedded in a common block. In the healthy adult rodents, enzyme activities were very intense. They demonstrated that aortic myocytes are capable of various synthesis and catabolism processes. However, considering the frequency of atherosclerosis and its phenotypes, significant differences appeared between the species studied. Our comparative study shows that aortic atherosensitive animals have several common metabolic characteristics, which are found in Psammomys rich in metachromatic glycosaminoglycans (involved in the inhibition of lipolysis and in calcification of the organic matrix), reduced activity in enzymes related to the Krebs cycle (weakening energetic power), and low lipolytic enzyme, adenosine triphosphatase, and adenosine diphosphatase activities. However, the most fundamental pathophysiological difference is the low lipolytic power of the aorta of Psammomys when compared to Wistar rats. This characteristic determines its atherosensitivity and makes this animal model more applicable to the experimental development of atherosclerosis.
英文关键词	diet-induced diabetes CVD atherosensitivity artery enzymatic activities histochemistry Psammomys obesus
类型	Article
语种	英语
开放获取类型	DOAJ Gold, Green Published
收录类别	ESCI
WOS记录号	WOS:000213939500031
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/329948
作者单位	[El-Aoufi, Salima; Lazourgui, Mohamed-Amine] USTHB, Fac Sci Biol, Lab Biol & Physiol Organismes MMDED, El Alia BP 32, Dar El Beida 16111, Algeria; [Griene, Lakhdar] CHU, Ctr Pierre & Marie Curie, Lab Hormonol, Mustapha, Algeria; [Maouche, Boubekeur] USTHB, Fac Chim, Lab Physicochim Theor & Chim Informat, Dar El Beida, Algeria
推荐引用方式 GB/T 7714	El-Aoufi, Salima,Lazourgui, Mohamed-Amine,Griene, Lakhdar,et al. Atherosclerosis and atherosensitivity in two southwest Algerian desert rodents, Psammomys obesus and Gerbillus gerbillus, and in Rattus norvegicus[J],2012,5:337-345.
APA	El-Aoufi, Salima,Lazourgui, Mohamed-Amine,Griene, Lakhdar,&Maouche, Boubekeur.(2012).Atherosclerosis and atherosensitivity in two southwest Algerian desert rodents, Psammomys obesus and Gerbillus gerbillus, and in Rattus norvegicus.DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY,5,337-345.
MLA	El-Aoufi, Salima,et al."Atherosclerosis and atherosensitivity in two southwest Algerian desert rodents, Psammomys obesus and Gerbillus gerbillus, and in Rattus norvegicus".DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY 5(2012):337-345.