干旱区生态环境知识资源中心(Arid): Simultaneous determination of multi-veterinary drug residues in honey by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry

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DOI	10.3724/SP.J.1123.2011.00535
	Simultaneous determination of multi-veterinary drug residues in honey by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry
	Hou Jianbo; Xie Wen; Chen Xiaomei; Xi Junyang; Qian Yan; Wang Feng; Liu Haishan
通讯作者	Xie, W
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2011
卷号	29 期号:6 页码:535-542
英文摘要	A method of solid phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) for simultaneous determination of 54 drug residues (sulfonamides, nitroimidazoles, quinolones, macrolides, lincosamides and praziquantel) in honey was developed. The honey samples were diluted by phosphate buffer solution (pH 8) followed by a further cleanup procedure with an Oasis (HLB) SPE column. The detection was carried out by LC-MS/MS, using positive-ion electrospray ionization in multiple reaction monitoring (MRM) mode, with one precursor/two product ion transitions for each compound. Isotope dilution internal standard method or external standard method was used to determine the residue contents with a good linear relationship (r > 0.992). The limits of quantification (LOQs, S/N > 10) were 1.0 mu g/kg for sulfonamides and nitroimidazoles, 2.0 mu g/kg for quinolones and lincosamides, 3.0 mu g/kg for macrolides, and 0.3 mu g/kg for praziquantel. The recovery ranges were from 32.6% to 114% with the relative standard deviations (RSDs) between 1.3% and 28.9%. As a screening method, the developed procedure is suitable for the determination and confirmation of the drug residues in honey samples.
英文关键词	liquid chromatography-tandem mass spectrometry (LC-MS/MS) multi-veterinary drug residues honey
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000435248800011
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/329862
作者单位	[Hou Jianbo; Xie Wen; Chen Xiaomei; Liu Haishan] Zhejiang Entry Exit Inspect & Quarantine Bur, Tech Ctr, Hangzhou 310016, Zhejiang, Peoples R China; [Hou Jianbo; Xie Wen; Chen Xiaomei; Liu Haishan] Zhejiang Acad Sci & Technol Inspect & Quarantine, Hangzhou 310016, Zhejiang, Peoples R China; [Xi Junyang; Qian Yan; Wang Feng] Zhejiang Lead Prod Tech Co Ltd, Hangzhou 310016, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Hou Jianbo,Xie Wen,Chen Xiaomei,et al. Simultaneous determination of multi-veterinary drug residues in honey by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry[J],2011,29(6):535-542.
APA	Hou Jianbo.,Xie Wen.,Chen Xiaomei.,Xi Junyang.,Qian Yan.,...&Liu Haishan.(2011).Simultaneous determination of multi-veterinary drug residues in honey by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,29(6),535-542.
MLA	Hou Jianbo,et al."Simultaneous determination of multi-veterinary drug residues in honey by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 29.6(2011):535-542.