干旱区生态环境知识资源中心(Arid): Determation of chlordimeform and its metabolite residues in honey using liquid chromatography-tandem mass spectrometry

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DOI	10.3724/SP.J.1123.2010.00649
	Determation of chlordimeform and its metabolite residues in honey using liquid chromatography-tandem mass spectrometry
	Yi Xionghai; Han Li; Yang Huiqin; Fan Xiang; Zhu Jian; Guo Dehua
通讯作者	Yi, XH
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2010
卷号	28 期号:7 页码:649-653
英文摘要	A liquid chromatography-tandam mass spectrometry (LC-MS/MS) method was developed for the determination of chlordimeform and its metabolite (4-chloro-0-toluidine) residue in acacia honey, chaste honey, comb honey, multifloral honey and wild honey. The samples were dissolved and diluted with sodium hydroxide solution, and cleaned up by a Waters Oasis HLB solid phase extraction column. The separation was performed on an Agilent XDB-C-18 column with gradient elution using 0.1% formic acid solution and acetonitrile. The residues of chlordimeform and its metabolite were determined by electrospray ionization-tandem mass spectrometry, and quantified by the method of matrix-matched external standard. The calibration curves for chlordimeform and its metabolite showed good linearity in the range of 2.5 - 250 mu g/L with the correlation coefficients (r) higher than 0.999. The limit of quantification was 5 mu g/kg, and the limit of detection was 2.5 mu g/kg. The recoveries of chlordimeform and 4-chloro-0-toluidine in honey at the spiked levels of 5,10 and 20 mu g/kg were in the ranges of 75.8% -113.8% and 85.6% - 114.3%, respectively. The relative standard deviations were 4.8% 10. 2% and 4.7% -9.1%, respectively. The method can meet the requirements for the determination of chlordimeform and 4-chloro-0-toluidine in honey for import and export inspection.
英文关键词	liquid chromatography-tandem mass spectrometry (LC-MS/MS) chlordimeform metabolite honey
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000435242700004
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/329597
作者单位	[Yi Xionghai; Han Li; Yang Huiqin; Fan Xiang; Zhu Jian; Guo Dehua] Shanghai Entry Exit Inspect & Quarantine Bur, Shanghai 200135, Peoples R China
推荐引用方式 GB/T 7714	Yi Xionghai,Han Li,Yang Huiqin,et al. Determation of chlordimeform and its metabolite residues in honey using liquid chromatography-tandem mass spectrometry[J],2010,28(7):649-653.
APA	Yi Xionghai,Han Li,Yang Huiqin,Fan Xiang,Zhu Jian,&Guo Dehua.(2010).Determation of chlordimeform and its metabolite residues in honey using liquid chromatography-tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,28(7),649-653.
MLA	Yi Xionghai,et al."Determation of chlordimeform and its metabolite residues in honey using liquid chromatography-tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 28.7(2010):649-653.