干旱区生态环境知识资源中心(Arid): Rapid determination of 3 nitromidazole residues in honey using liquid chromatography-tandem mass spectrometry

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DOI	10.3724/SP.J.1123.2010.00596
	Rapid determination of 3 nitromidazole residues in honey using liquid chromatography-tandem mass spectrometry
	Liu Yongming; Cao Yanzhong; Li Jin; Wu Yanping; Zhang Jinjie; Li Xuemin; Ge Na
通讯作者	Liu, YM
来源期刊	CHINESE JOURNAL OF CHROMATOGRAPHY
ISSN	1000-8713
出版年	2010
卷号	28 期号:6 页码:596-600
英文摘要	A method was developed for the rapid determination of 3 nitromidazole residues in honey, including metronidazole, ronidazole and dimetridazole, using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The honey sample was dissolved in water, and the solution was cleaned up with an Oasis HLB cartridge. The cartridge was washed with water and methanol-water solution (1:9, v/v) in turn, and eluted with ethyl acetate. The solution was concentrated and then analyzed by LC-MS/MS. External calibration was used for quantitative determination. The recoveries and relative standard deviations (n = 8) were from 76.6% to 89.7% and 5.2% to 9.9%, at the spiked levels of 0.05 -2.0 mu g/kg, respectively. The limits of detection were 0.1 mu g/kg for metronidazole, and 0.2 mu g/kg for ronidazole and dimetridazole. The method was successfully applied for the inspection of exported honey. With simple and fast sample preparation, the method is sensitive and specific for the determination. The sensitivity and accuracy of the method meet the requirements of the inspection for the 3 nitromidazole residues in honey in Japan and European Union.
英文关键词	liquid chromatography-tandem spectrometry (LC-MS/MS) metronidazole ronidazole dimetridazole honey
类型	Article
语种	中文
收录类别	ESCI
WOS记录号	WOS:000435242600012
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/329596
作者单位	[Liu Yongming; Cao Yanzhong; Li Jin; Wu Yanping; Zhang Jinjie; Li Xuemin; Ge Na] Qinhuangdao Entry Exit Inspect & Quarantine Bur, Qinhuangdao 066004, Peoples R China
推荐引用方式 GB/T 7714	Liu Yongming,Cao Yanzhong,Li Jin,et al. Rapid determination of 3 nitromidazole residues in honey using liquid chromatography-tandem mass spectrometry[J],2010,28(6):596-600.
APA	Liu Yongming.,Cao Yanzhong.,Li Jin.,Wu Yanping.,Zhang Jinjie.,...&Ge Na.(2010).Rapid determination of 3 nitromidazole residues in honey using liquid chromatography-tandem mass spectrometry.CHINESE JOURNAL OF CHROMATOGRAPHY,28(6),596-600.
MLA	Liu Yongming,et al."Rapid determination of 3 nitromidazole residues in honey using liquid chromatography-tandem mass spectrometry".CHINESE JOURNAL OF CHROMATOGRAPHY 28.6(2010):596-600.