干旱区生态环境知识资源中心(Arid): Scientific Opinion on marine biotoxins in shellfish

Arid

DOI	10.2903/j.efsa.2010.1627
	Scientific Opinion on marine biotoxins in shellfish - Emerging toxins: Ciguatoxin group
	Alexander, Jan; Benford, Diane; Boobis, Alan; Ceccatelli, Sandra; Cravedi, Jean-Pierre; Di Domenico, Alessandro; Doerge, Daniel; Dogliotti, Eugenia; Edler, Lutz; Farmer, Peter; Filipic, Metka; Fink-Gremmels, Johanna; Fuerst, Peter; Guerin, Thierry; Knutsen, Helle Katrine; Machala, Miroslav; Mutti, Antonio; Schlatter, Josef; van Leeuwen, Rolaf
通讯作者	Alexander, J
来源期刊	EFSA JOURNAL
EISSN	1831-4732
出版年	2010
卷号	8 期号:6
英文摘要	The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the consumption of ciguatoxin (CTX)-group toxins in fish. CTX-group toxins occur in fish as a result of biotransformation of precursor gambiertoxins produced by the benthic dinoflagellate Gambierdiscus toxicus. CTX-group toxins cause ciguatera fish poisoning. They are mainly found in Pacific, Caribbean and Indian Ocean regions and are classified as Pacific (P), Caribbean (C) and Indian Ocean (I) CTX-group toxins. Recently CTX-group toxins were identified for the first time in fish in Europe. Currently there are no regulatory limits for CTX-group toxins in fish in Europe, but the regulation requires that no fish products containing CTX-group toxins are placed on the market. The toxicological database for CTX-group toxins is limited, comprising mostly acute toxicity studies. In view of the acute toxicity of CTX-group toxins the CONTAM Panel considered establishing an acute reference dose (ARID). However, due to the very limited quantitative data both in experimental animals as well as related to human intoxications, the CONTAM Panel concluded that the establishment of an oral ARfD was not possible. Based on case reports on human intoxications it appears that a concentration of 0.01 tg P-CTX-1 equivalents/kg fish is expected not to exert effects in sensitive individuals when consuming a single fish meal. The mouse bioassay (MBA) has been widely used to detect CTX-group toxins. However, due to insufficient detection capability and ethical concerns the MBA is not considered an appropriate method. In vitro (cytotoxicity and receptor binding) assays have been developed as alternative, but they need further development. Liquid chromatography-tandem mass spectrometry methods can be of value for the quantification of CTX-group toxins, but certified reference standards and reference materials need to be provided to allow method development and (inter-laboratory) validation.
英文关键词	Marine biotoxins emerging toxins ciguatoxin (CTX)-group toxins fish methods of analysis human health risk assessment
类型	Article
语种	英语
开放获取类型	DOAJ Gold
收录类别	ESCI
WOS记录号	WOS:000408933000013
WOS关键词	MEMBRANE IMMUNOBEAD ASSAY ; RAPID ENZYME-IMMUNOASSAY ; GUINEA-PIG ATRIA ; CARIBBEAN CIGUATOXINS ; GYMNOTHORAX-JAVANICUS ; MULTIPLE CIGUATOXINS ; CIGUATERA ; FISH ; GAMBIERDISCUS ; BREVETOXINS
WOS类目	Food Science & Technology
WOS研究方向	Food Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/329512
作者单位	[Alexander, Jan; Benford, Diane; Boobis, Alan; Ceccatelli, Sandra; Cravedi, Jean-Pierre; Di Domenico, Alessandro; Doerge, Daniel; Dogliotti, Eugenia; Edler, Lutz; Farmer, Peter; Filipic, Metka; Fink-Gremmels, Johanna; Fuerst, Peter; Guerin, Thierry; Knutsen, Helle Katrine; Machala, Miroslav; Mutti, Antonio; Schlatter, Josef; van Leeuwen, Rolaf] EFSA, Parma, Italy
推荐引用方式 GB/T 7714	Alexander, Jan,Benford, Diane,Boobis, Alan,et al. Scientific Opinion on marine biotoxins in shellfish - Emerging toxins: Ciguatoxin group[J],2010,8(6).
APA	Alexander, Jan.,Benford, Diane.,Boobis, Alan.,Ceccatelli, Sandra.,Cravedi, Jean-Pierre.,...&van Leeuwen, Rolaf.(2010).Scientific Opinion on marine biotoxins in shellfish - Emerging toxins: Ciguatoxin group.EFSA JOURNAL,8(6).
MLA	Alexander, Jan,et al."Scientific Opinion on marine biotoxins in shellfish - Emerging toxins: Ciguatoxin group".EFSA JOURNAL 8.6(2010).