干旱区生态环境知识资源中心(Arid): Treatment Options in Acute Coronary Syndromes: Focus on Fondaparinux Sodium

Arid

DOI	10.4137/CMT.S2197
	Treatment Options in Acute Coronary Syndromes: Focus on Fondaparinux Sodium
	Reindl, Iris; Schlitt, Axel
通讯作者	Reindl, I
来源期刊	CLINICAL MEDICINE INSIGHTS-THERAPEUTICS
ISSN	1179-559X
出版年	2010
卷号	2 页码:869-876
英文摘要	Anticoagulants are the mainstay for treating thromboembolism and acute coronary syndromes (ACS). In comparison to -heparin newer agents such as bivalirudin and fondaparinux have improved the outcome of ACS in patients managed by using an invasive or conservative strategy, respectively. Using antithrombotic therapy, however, we need to strike a careful balance between reducing ischemic events and running an increased risk of bleeding complications. Fondaparinux is the first selective inhibitor of the -coagulation factor Xa that is commercially available for clinical use. This new drug was accepted for priority review by the Food and Drug Administration based on the positive results of two pivotal, phase III trials (OASIS 5 and 6) that evaluated its role in the treatment of patients with acute coronary syndromes. Fondaparinux was associated with a significantly lower rate of bleeding than enoxaparin in the first 9 days, and at 3 and 6 months, respectively, resulting in a lower long-term mortality and morbidity in comparison to -enoxaparin. A small, but definite increase in the risk of catheter-related thrombosis has been found among patients undergoing percutaneous -coronary interventions, which is ameliorated by administering unfractionated heparin during the procedure.
英文关键词	acute coronary syndrome fondaparinux treatment options
类型	Review
语种	英语
开放获取类型	Other Gold
收录类别	ESCI
WOS记录号	WOS:000215767200079
WOS关键词	MOLECULAR-WEIGHT HEPARIN ; PREVENTING THROMBUS FORMATION ; ACUTE MYOCARDIAL-INFARCTION ; MECHANICAL HEART-VALVES ; HIP-REPLACEMENT SURGERY ; UNFRACTIONATED HEPARIN ; VENOUS THROMBOEMBOLISM ; ST-ELEVATION ; POSTOPERATIVE FONDAPARINUX ; ASSESS STRATEGIES
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/329455
作者单位	[Reindl, Iris; Schlitt, Axel] Martin Luther Univ Halle Wittenberg, Dept Med 3, Halle, Germany
推荐引用方式 GB/T 7714	Reindl, Iris,Schlitt, Axel. Treatment Options in Acute Coronary Syndromes: Focus on Fondaparinux Sodium[J],2010,2:869-876.
APA	Reindl, Iris,&Schlitt, Axel.(2010).Treatment Options in Acute Coronary Syndromes: Focus on Fondaparinux Sodium.CLINICAL MEDICINE INSIGHTS-THERAPEUTICS,2,869-876.
MLA	Reindl, Iris,et al."Treatment Options in Acute Coronary Syndromes: Focus on Fondaparinux Sodium".CLINICAL MEDICINE INSIGHTS-THERAPEUTICS 2(2010):869-876.