干旱区生态环境知识资源中心(Arid): Management of acute coronary syndromes with fondaparinux

Arid

	Management of acute coronary syndromes with fondaparinux
	Wienbergen, Harm; Zeymer, Uwe
通讯作者	Wienbergen, H
来源期刊	VASCULAR HEALTH AND RISK MANAGEMENT
ISSN	1176-6344
EISSN	1178-2048
出版年	2007
卷号	3 期号:3 页码:321-329
英文摘要	Fondaparinux is the first selective inhibitor of the coagulation factor Xa which is commercially avaliable for clinical use. It has been approved for the prevention of venous thromboembolism in patients undergoing orthopedic surgery and for the initial therapy of venous thromboembolism. In randomized clinical trials the value of fondaparinux in the treatment of ST-elevation myocardial infarction (STEMI) has been investigated. The PENTALYSE study showed that fondaparinux was at least as effective and safe as unfractionated heparin in 333 patients with STEMI undergoing fibrinolysis with t-PA. In the recent large OASIS-6 trial with 12,092 patients the treatment with 2.5 mg fondaparinux daily significantly reduced death and reinfarctions until day 30 compared with guideline recommended usual care and compared with unfractionated heparin (9.7% vs 11.2%, p = 0.008) without increasing major bleedings (1.0% vs 1.3%, p = 0.13). This advantage was predominantly seen in the subgroups of patients with fibrinolysis and without early reperfusion therapy. However, in the subgroup of primary percutaneous coronary interventions (PCIs) no clinical benefit of fondaparinux was found, but there were more catheter thrombosis and acute thrombotic complications. In summary, fondaparinux is a new antithrombin that is an efficient, safe, and easy to use in treatment for STEMI patients, particularly those not undergoing primary PCI.
英文关键词	selective factor Xa inhibition fondaparinux acute ST-elevation myocardial infarction antithrombin therapy
类型	Review
语种	英语
收录类别	ESCI
WOS记录号	WOS:000210207300009
WOS类目	Peripheral Vascular Disease
WOS研究方向	Cardiovascular System & Cardiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/328842
作者单位	[Wienbergen, Harm; Zeymer, Uwe] Herzzentrum Ludwigshafen, Med Klin B, Bremserstr 79, D-67063 Ludwigshafen, Germany
推荐引用方式 GB/T 7714	Wienbergen, Harm,Zeymer, Uwe. Management of acute coronary syndromes with fondaparinux[J],2007,3(3):321-329.
APA	Wienbergen, Harm,&Zeymer, Uwe.(2007).Management of acute coronary syndromes with fondaparinux.VASCULAR HEALTH AND RISK MANAGEMENT,3(3),321-329.
MLA	Wienbergen, Harm,et al."Management of acute coronary syndromes with fondaparinux".VASCULAR HEALTH AND RISK MANAGEMENT 3.3(2007):321-329.