Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.1080/15592294.2020.1809852 |
| DNA methylation profiles unique to Kalahari KhoeSan individuals | |
| Goncearenco, Alexander; LaBarre, Brenna A.; Petrykowska, Hanna M.; Jaratlerdsiri, Weerachai; Bornman, M. S. Riana; Turner, Stephen D.; Hayes, Vanessa M.; Elnitski, Laura | |
| 通讯作者 | Elnitski, L |
| 来源期刊 | EPIGENETICS
 |
| ISSN | 1559-2294 |
| EISSN | 1559-2308 |
| 英文摘要 | Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting lifestyle. Given these dramatic environmental differences, and the responsiveness of the methylome to environmental exposures of many types, we hypothesized that DNA methylation patterns would differ between KhoeSan and neighbouring agropastoral and/or industrial Bantu. We analysed Illumina HumanMethylation 450 k array data generated from blood samples from 38 KhoeSan and 42 Bantu, and 6 Europeans. After removing CpG positions associated with annotated and novel polymorphisms and controlling for white blood cell composition, sex, age and technical variation we identified 816 differentially methylated CpG loci, out of which 133 had an absolute beta-value difference of at least 0.05. Notably SLC39A4/ZIP4, which plays a role in zinc transport, was one of the most differentially methylated loci. Although the chronological ages of the KhoeSan are not formally recorded, we compared historically estimated ages to methylation-based calculations. This study demonstrates that the epigenetic profile of KhoeSan individuals reveals differences from other populations, and along with extensive genetic diversity, this community brings increased accessibility and understanding to the diversity of the human genome. |
| 英文关键词 | Methylation epigenome Illumina methylation array methylation probes single nucleotide variants Khoesan |
| 类型 | Article ; Early Access |
| 语种 | 英语 |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000567022800001 |
| WOS关键词 | HEALTH |
| WOS类目 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/328215 |
| 作者单位 | [Goncearenco, Alexander; LaBarre, Brenna A.; Elnitski, Laura] NHGRI, Genom Funct Anal Sect, Translat & Funct Genom Branch, NIH, 49 Convent Dr, Bethesda, MD 20892 USA; [LaBarre, Brenna A.; Petrykowska, Hanna M.] Boston Univ, Grad Program Bioinformat, Boston, MA 02215 USA; [Jaratlerdsiri, Weerachai; Hayes, Vanessa M.] Garvan Inst Med Res, Lab Human Comparat & Prostate Canc Genom, Darlinghurst, NSW, Australia; [Bornman, M. S. Riana; Hayes, Vanessa M.] Univ Pretoria, Sch Hlth Syst & Publ Hlth, Pretoria, South Africa; [Turner, Stephen D.] Univ Virginia, Sch Med, Div Biomed Informat, Charlottesville, VA 22908 USA; [Hayes, Vanessa M.] Univ Limpopo, Fac Hlth Sci, Sovenga, South Africa; [Hayes, Vanessa M.] Univ Sydney, Sydney Med Sch, Camperdown, NSW, Australia |
| 推荐引用方式 GB/T 7714 | Goncearenco, Alexander,LaBarre, Brenna A.,Petrykowska, Hanna M.,et al. DNA methylation profiles unique to Kalahari KhoeSan individuals[J]. |
| APA | Goncearenco, Alexander.,LaBarre, Brenna A..,Petrykowska, Hanna M..,Jaratlerdsiri, Weerachai.,Bornman, M. S. Riana.,...&Elnitski, Laura. |
| MLA | Goncearenco, Alexander,et al."DNA methylation profiles unique to Kalahari KhoeSan individuals".EPIGENETICS |
| 条目包含的文件 | 条目无相关文件。 | |||||
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