干旱区生态环境知识资源中心(Arid): Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma

Arid

DOI	10.1038/s41379-020-0633-x
	Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma
	Kim, So-Woon; Kim, Young Il; Mustafa, Bilal; Kim, Mi-Ju; Jeong, Gowun; Ahn, Sung-Min; Lim, Seok-Byung; Yu, Chang Sik; Kim, Jin Cheon; Hong, Seung-Mo; Park, In Ja
通讯作者	Hong, SM
来源期刊	MODERN PATHOLOGY
ISSN	0893-3952
EISSN	1530-0285
英文摘要	Anorectal malignant melanoma (ARMM) is a rare disease with poor prognosis. Determining ARMM prognosis precisely is difficult due to the lack of proper assessment techniques. Immunotherapy has proven effective against cutaneous malignant melanoma and may show efficacy in ARMM. Herein, we assessed the immune profile of ARMM to identify possible prognostic biomarkers. Twenty-two ARMM formalin-fixed and paraffin-embedded samples were evaluated using an nCounter(R)PanCancer Immune Profiling Panel. Validation was performed through immunohistochemical staining for CD3, CD8, Foxp3, CD68, CD163, and PD-L1. RNA analysis revealed significantly decreased scores for pathways involved in cell regulation and function, as well as chemokines, in recurrent patients compared to nonrecurrent patients. In cell-type profiling, the recurrent cases displayed significantly low tumor infiltrating lymphocyte (TIL) scores. Recurrence/death prediction models were defined using logistic regression and showed significantly lower scores in recurrent and deceased patients (all,P < 0.001) compared to those in nonrecurrent and surviving patients. The high total TIL and tumor-associated macrophage (TAM) groups had significantly better overall survival outcomes compared to the low total TIL and TAM groups (P = 0.007 andP = 0.035, respectively). In addition, the presence of CD3 + TILs in the invasion front was an independent favorable prognostic indicator (P = 0.003, hazard ratio = 0.21, 95% confidential interval, 0.01-0.41). Patients with inflamed or brisk-infiltration type tumors also had a significantly better overall survival than that of patients with immune-desert/excluded and absent/non-brisk type tumors (P = 0.03 andP = 0.0023, respectively). In conclusion, TILs have a strong prognostic value in ARMM, and the quantification of TILs and an analysis of the TIL phenotype and infiltration pattern during pathological diagnosis are essential to guide treatment strategies and accurate prognosis in ARMM.
类型	Article ; Early Access
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000552168700001
WOS关键词	REGULATORY T-CELLS ; BRAF MUTATIONS ; CUTANEOUS MELANOMA ; IMMUNE CELLS ; SURVIVAL ; CANCER ; IPILIMUMAB ; PREDICTOR ; PD-L1 ; PHASE
WOS类目	Pathology
WOS研究方向	Pathology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/328113
作者单位	[Kim, So-Woon; Hong, Seung-Mo] Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul, South Korea; [Kim, So-Woon] Kyung Hee Univ, Kyung Hee Univ Hosp, Dept Pathol, Coll Med, Seoul, South Korea; [Kim, Young Il; Lim, Seok-Byung; Yu, Chang Sik; Kim, Jin Cheon; Park, In Ja] Univ Ulsan, Asan Med Ctr, Dept Colon & Rectal Surg, Coll Med, Seoul, South Korea; [Mustafa, Bilal] Gachon Univ, Gachon Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Incheon, South Korea; [Kim, Mi-Ju] Asan Med Ctr, Asan Inst Life Sci, Seoul, South Korea; [Jeong, Gowun] SK Telecom, AI Ctr, Data Machine Intelligence Grp, Seoul, South Korea; [Ahn, Sung-Min] Gachon Univ, Coll Med, Dept Genome Med & Sci, Incheon, South Korea
推荐引用方式 GB/T 7714	Kim, So-Woon,Kim, Young Il,Mustafa, Bilal,et al. Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma[J].
APA	Kim, So-Woon.,Kim, Young Il.,Mustafa, Bilal.,Kim, Mi-Ju.,Jeong, Gowun.,...&Park, In Ja.
MLA	Kim, So-Woon,et al."Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma".MODERN PATHOLOGY