干旱区生态环境知识资源中心(Arid): Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum

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DOI	10.1080/14786419.2020.1788554
	Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum
	Shi, Wen-Pan; Zeng, Hong; Wan, Chuan-Xing; Zhou, Zhong-Bo
通讯作者	Wan, CX ; Zhou, ZB
来源期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
EISSN	1478-6427
英文摘要	In our study, the anti-quorum sensing (QS) activity of fermentation broth from TRM B-02, a bacterium isolated from Taklimakan desert, was investigated using the biosensor bioassay on Chromobacterium violaceum ATCC12472. TRM B-02 was 100% similar to Bacillus subtilis subsp. Inaquosorum KCTC 13429((T)) by genotypic and phenotypic analyses. Based on anti-QS activity tracking, six known amicoumacins, named as Al-77-H (1), Al-77-F (2), amicoumacin B (3), amicoumacin C (4), Al-77-C (5) and bacilosarcins D (6), were isolated and identified. Among them, compounds 1-3 exhibited a better inhibitory effect on C. violaceum ATCC12472. Further research suggested that compounds 1-3 could significantly down-regulate the expressions of violacein operon A (vioA), vioB, vioD and vioE and up-regulate vioC. Docking experiments indicated that compounds 1-3 may act as an inhibitor of violacein biosynthetic pathway competitively inhibiting the binding of flavin adenine dinucleotide (FAD) with the vioD enzyme. [GRAPHICS] .
英文关键词	Quorum sensing inhibitor Bacillus subtilis amicoumacins
类型	Article ; Early Access
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000547030700001
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/328083
作者单位	[Shi, Wen-Pan; Zeng, Hong; Wan, Chuan-Xing; Zhou, Zhong-Bo] Tarim Univ, Xinjiang Prod & Construct Corps Key Lab Protect &, Alaer, Peoples R China; [Zhou, Zhong-Bo] Tarim Univ, Engn Lab Chem Resources Utilizat South Xinjiang X, Alaer, Peoples R China
推荐引用方式 GB/T 7714	Shi, Wen-Pan,Zeng, Hong,Wan, Chuan-Xing,et al. Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum[J].
APA	Shi, Wen-Pan,Zeng, Hong,Wan, Chuan-Xing,&Zhou, Zhong-Bo.
MLA	Shi, Wen-Pan,et al."Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum".NATURAL PRODUCT RESEARCH